We present the microfabrication and characterization of a ball valve micropump in glass, which is magnetically actuated using the sinusoidal current of an external electromagnet. We employ the use of a simple powder blasting technology for microstructuring the glass substrates and fusion bonding for assembly of the multi-layered microfluidic chip. The use of a polymer membrane with embedded per...

In this article, we demonstrate a novel microfluidic flow chamber driven by surface acoustic waves. Our device is a closed loop channel with an integrated acoustic micropump without external fluidic connections that allows for the investigation of small fluid samples in a continuous flow. The fabrication of the channels is particularly simple and uses standard milling and PDMS molding. The micr...

BACKGROUND Ribavirin is an antiviral drug that can be administered by inhalation. Despite advancements in the oral delivery of this medication, there has been a renewed interested in delivering ribavirin via the pulmonary system. Although data are not conclusive that inhaled ribavirin improves outcomes, we set out to determine whether delivery by a newer generation nebulizer, the vibrating mesh...

This paper demonstrates a modular architecture of a non-contact actuation micropump setup. Rapid hot embossing prototyping was employed in micropump fabrication by using printed circuit board (PCB) as a mold material in polymer casting. Actuator-membrane gap separation was studied, with experimental investigation of three separation distances: 2.0 mm, 2.5 mm and 3.5 mm. To enhance the micropump...

This paper briefly overviews progress on the development of MEMS-based micropumps and their applications in drug delivery and other iomedical applications such as micrototal analysis systems ( TAS) or lab-on-a-chip and point of care testing systems (POCT). The focus of the eview is to present key features of micropumps such as actuation methods, working principles, construction, fabrication met...

This paper reports a novel cerebrospinal fluid (CSF) shunt system for the hydrocephalus patients. The CSF shunt system consists of a micro telemetry pressure sensor, an electromagnetic micropump and a controller. The pressure sensor has a flexible p+ diaphragm and a planar copper coil that construct an LC resonant circuit. The cerebrospinal pressure is measured from the phase shift at the reson...

We discuss the successful transport of jurkat cells and 5D10 hybridoma cells using a reciprocating micropump with nozzle-diffuser elements. The effect of the pumping action on cell viability and proliferation, as well as on the damaging of cellular membranes is quantified using four types of well-established biological tests: a trypan blue solution, the tetrazolium salt WST-1 reagent, the LDH c...

Biomedical Micro Electro Mechanical Systems (Bio-MEMS) have been applied to the development of a variety of health care related products including health Monitoring Systems (HMS) and Drug Delivery Systems (DDS). We focus on research to develop the new type compact medical device used for blood sugar control. The new type compact medical device comprises (1) a micropump system to extract blood u...

Abstract In this paper, ZnO nanorods are combined with the driving mechanism of a piezoelectric micropump to design valveless micropump. The were prepared by magnetron sputtering method grow seed crystal layer on silicon surface and then hydrothermal method. growth under different solution concentrations, temperatures, times was investigated, analytical methods for analyzing morphology elementa...

This paper presents a novel dosing concept for drug delivery based on a peristaltic piezo-electrically actuated micro membrane pump. The design of the silicon micropump itself is straight-forward, using two piezoelectrically actuated membrane valves as inlet and outlet, and a pump chamber with a piezoelectrically actuated pump membrane in-between. To achieve a precise dosing, this micropump is ...