Abstract: Aim/Background: The purpose of the study was to fabricate and evaluate atenolol loaded micro-sponge in-situ gel. Materials Methods: Oil in Emulsion Solvent Diffusion Technique used for formulation microsponges by using different levels polymers such as Eudragit RS-100 Ethyl Cellulose. prepared micro-sponges were evaluated optical microscopy, percentage yield, drug content, entrapment ...

During the last few decades, pharmaceutical industry gave more importance to controlled release of dosage forms like solid formulation, semi and topicalpreparation dueto efficacy patient compliance. Normal topical preparations have some disadvantages unpleasant odour, greasiness, skin irritation reported in study cases. Also many topicalpreparations fail reach systemic circulation sufficient am...

benzoyl peroxide (bpo) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. skin irritation is a common side effect, and it has been shown that controlled release of bpo from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. therefore, the purpose of the pres...