نتایج جستجو برای: microtubuleassociated protein2
تعداد نتایج: 192 فیلتر نتایج به سال:
With the emerging proteomics era the scientific community is beginning the daunting task of understanding the structures and functions of a large number of selfassembling proteins. Here, our study was concerned with the effect of the microtubuleassociated-protein (MAP) tau on the assembled structure of taxol-stabilized microtubules. Significantly, the synchrotron small angle x-ray scattering (S...
Current risk assessment methods for environmental chemicals are based on adult physiology. However, recent reports have shown an increased incidence of neurodevelopmental disorders which may result from exposure to chemical in utero and during the early postnatal period. We previously showed that exposure of neonates to the environmental chemical p-nitrotoluene caused hyperactivity, accompanied...
β-mercaptoethanol can induce adult adipose-derived stromal cells to rapidly and efficiently differentiate into typical neuron-like cells in vitro. Immunohistochemistry showed that neuron specific enolase and neurofilament-200 expression gradually increased with the extension of induction time, and peaked at 5 hours. By contrast, glial fibrillary acidic protein was negatively expressed at all ti...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubuleassociated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and their disassembly. The sites are prominent in tau from Alzheimer's disease brains. We studied the activation of MARK and identi®ed the upstream kinase, MARKK, a member of the Ste20 kinase family. It ...
Protein turnover can be achieved via the lysosome/vacuole and the autophagic degradation pathways. Evidence has accumulated revealing that efficient autophagic degradation requires functional endosomal sorting complex required for transport (ESCRT) machinery. However, the interplay between the ESCRT machinery and the autophagy regulator remains unclear. Here, we show that FYVE domain protein re...
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