The multi-residue determination of organophosphorus pesticides (OPs) is an important task due to the wide application and high toxicity of OPs. However, there is no promising immunoassay to monitor the multi-residue of O,O-dimethyl OPs. In this study, a monoclonal antibody (mAb) against a generic hapten of O,O-dimethyl OPs (O,O-dimethyl O-(3-carboxyphenyl)phosphorothioate) was prepared. To deve...

Mouse monoclonal antibody (mAb) BCD-F9, which recognizes an unknown antigen found on the surface of many tumor cells, was used to screen a phage display library expressing random peptide decamers. The phage that was selected encoded the unique sequence GRRPGGWWMR, representing the peptide capable of binding to the BCD-F9 mAb. The peptide was synthesized and found to specifically inhibit the bin...

The passive application of Trastuzumab and Pertuzumab has demonstrated remarkable success in the clinical outcome patients with Her-2/neu positive metastatic breast cancer. However, active immunization mimotope/B cell epitope-based vaccines can induce production corresponding mAbs by patient’s immune system. We have developed a B peptide-based vaccine (HerVaxx) comprising Trastuzumab’s binding ...