نتایج جستجو برای: mineralocorticoid receptor
تعداد نتایج: 591331 فیلتر نتایج به سال:
Aldosterone plays an important role in the pathogenesis of cardiovascular and renal disease that is independent of angiotensin II. Mineralocorticoid receptors are expressed in nonepithelial tissues such as the heart and blood vessels. Although mineralocorticoid receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of ...
PURPOSE OF REVIEW This review highlights recent clinical studies demonstrating the contribution of aldosterone to cardiovascular mortality, vascular dysfunction, and renal injury in the context of advances in our understanding of the molecular biology of aldosterone. RECENT FINDINGS Mineralocorticoid receptor antagonism reduces mortality in patients with congestive heart failure and following...
• Corticosteroids function to optimize the stress response and are thus essential for the organism to cope with the stressor. • Corticosteroid signaling is mediated by two receptors: the high-affinity mineralocorticoid receptor and the low-affinity glucocorticoid receptor. • Imbalance between central glucocorticoid and mineralocorticoid receptor affects the secretion of corticosteroids and has ...
Metabolic syndrome is a highly predisposing condition for cardiovascular disease and could be a cause of excess salt-induced organ damage. Recently, several investigators have demonstrated that salt loading causes left ventricular diastolic dysfunction associated with increased oxidative stress and mineralocorticoid receptor activation. We, therefore, investigated whether excess salt induces ca...
Grotjohann, Ingo, Jörg-Dieter Schulzke, and Michael Fromm. Electrogenic Na1 transport in rat late distal colon by natural and synthetic glucocorticosteroids. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G491–G498, 1999.—The potency of in vitro-added corticosteroids to stimulate electrogenic Na1 absorption (JNa, the Na1 absorptive short-circuit current blockable by 1024 M amiloride) wa...
Activation of the mineralocorticoid receptor has been shown to be deleterious in cardiovascular diseases (CVDs). We have recently shown that lipocalin 2 (Lcn2), or neutrophil gelatinase-associated lipocalin (NGAL), is a primary target of aldosterone/mineralocorticoid receptor in the cardiovascular system. Lcn2 is a circulating protein, which binds matrix metalloproteinase 9 and modulates its st...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید