Borrelia hermsii, a spirochete and an etiological agent of relapsing fever, was cultivated in modified Kelly medium. Studies of the action of penicillin on B. hermsii strain HS1 revealed the following: (i) the in vitro minimum inhibitory concentration and minimum bactericidal concentration of benzylpenicillin for this strain were 0.4 and 3.1 nmol/ml (0.15 and 1.1 micrograms/ml), respectively; (...

quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. in this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution alamar blue ® assay against six strains of bacteria (three gram-positive and three gram-negative) and three strains of f...

BACKGROUND The purpose of this study was to evaluate the antimicrobial activity of two nitric oxide donors, ie, S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylcysteine (SNAC), against clinical isolates from patients with infectious keratitis. METHODS Reference broth microdilution assays were performed to determine the minimum inhibitory and bactericidal concentrations for GSNO and SNAC aga...

BACKGROUND Use of herbal extracts and essences as natural antibacterial compounds has become increasingly popular for the control of oral infectious diseases. Therefore, finding natural antimicrobial products with the lowest side effects seems necessary. The present study sought to assess the effect of Punica granatum L. water extract on five oral bacteria and bacterial biofilm formation on ort...

abstract aims: bovine mastitis continues to be the most costly disease to the dairy farmers. it dominates in iran as one of the most prevalent diseases in dairy cattle among the dairy farms. mastitis treatment with antibiotics leads to the development of antibiotic resistant strains and consumer health problem. this study was performed for the first time to analyze in vitro effects of hydro-alc...

The rate of inactivation of metronidazole in vitro was determined during the course of time-kill curves against anaerobic and aerobic bacteria in the stationary phase of growth. Metronidazole at a concentration of 10 mug/ml, as measured by bioassay, was rapidly inactivated in broth culture by susceptible anaerobic bacteria (minimum bactericidal concentration </= 3 mug/ml), and this correlated c...

This manuscript describes the synthesis of new Au(I) and Ag(I) complexes with aminophosphane ligands and a study of their antibacterial activity against Gram-negative Salmonella enterica serovar typhimurium and Escherichia coli and Gram-positive Listeria monocytogenes and Staphylococcus aureus. The bactericidal assays revealed the effectiveness of these compounds on paradigm Gram-negative and G...