micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

intoduction: the discovery of micrornas (mirnas), an extensive family of small non-protein-coding rnas, provided an exciting era in cancer research and recent findings have prompted us to revise the traditional concept of cancer. deregulated mirnas   expression influences biological events leading to cancer such as proliferation, differentiation, metastasis and apoptosis. the expression of onco...

results researchers have reported that mirnas can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. during the past two decades, numerous studies have shown that mirnas play an essential role in inhibiting hcc via several different pathways. deregulated mirnas may contribute to carcinogenesis, indicating that mirnas can act a...

objective(s):micrornas (mirnas) are a class of short rnas that control the biological processes including cell proliferation, apoptosis and development. aberrant expression of mirnas was determined in the different stages of tumor development and metastasis. to study the effect of silibinin on mirnas expression, we evaluated quantitative expression of mir-21 and mir-155 as two oncomirs and seve...

Background: Human umbilical cord blood (HUCB) is an acceptable and readily accessible source of stem cells. There is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated HUCB cells. The involvement of miRNAs in several biological processes has been shown. The aim of this study was to ev...

objective(s): study of non-coding rnas is considerable to elucidate principal biological questions or design new therapeutic strategies. mirnas are a group of non-coding rnas that their functions in pi3k/akt signaling and apoptosis pathways after t cell activation is not entirely clear. herein, mirnas expression and their putative targets in the mentioned pathways were studied in the activated ...

multiple myeloma (mm), is the second most common blood cancer after non-hodgkin’s lymphoma. genetic changes, structural and numerical chromosome anomalies, are involved in pathogenesis of mm, and are among the most important prognostic factors of disease-associated patient survival. micrornas (mirnas) are small 19-22 nucleotide single-stranded rnas involved in important cellular processes. cyto...

Objective(s): Study of non-coding RNAs is considerable to elucidate principal biological questions or design new therapeutic strategies. miRNAs are a group of non-coding RNAs that their functions in PI3K/AKT signaling and apoptosis pathways after T cell activation is not entirely clear. Herein, miRNAs expression and their putative targets in the mentioned pathways were studied in the activated ...

objective(s):an earlier meta-analysis on gene expression data derived from four microarray, two cdna library, and one sage experiment had identified rgs5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (tm) cells by all studies. rgs5 encodes regulator of g-protein signaling-5. the tm tissue is the route of aqueous fluid outflow, and is r...