• IF 1 regulates MCU-dependent mitochondrial Ca 2+ uptake. loss induces MCU upregulation through activation of the AMPK/CREB pathway. OMA1 depletion restores physiological levels and entry.

introduction: neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as alzheimer’s disease, parkinson’s disease and etc. gemfibrozil is used as a therapeutic drug for hyperlipidemia. it has been shown that gemfibrozil is neuroprotecti...

Mitochondrial and autophagy dysfunction are mechanisms proposed to be involved in the pathogenesis of several neurodegenerative diseases. Huntington's disease (HD) is a progressive disorder associated with mutant Huntingtin-induced abnormalities neuronal mitochondrial dynamics quality control. Former studies suggest that removal defective mitochondria may compromised HD. control (MQC) complex, ...

Cells undergo apoptosis mainly via two pathways-the mitochondrial pathway and the cytosolic pathway. It has been well documented that activation of the mitochondrial pathway promotes mitochondrial fragmentation and inhibition of mitochondrial fragmentation partly represses cell death. However, the mitochondrial events following activation of the cytosolic pathway are less understood. In this st...

Despite recent improvements in treatment, ovarian cancer is still the leading cause of death from gynaecological malignancies. Today, marine mollusks are considered as natural source of new biologically and pharmacologically active compounds by scientists and the pharmaceutical industries. The aim of this study is to investigate the selective apoptotic effects of Turbo coronatus crude extract f...

Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore complex that plays a role in the PT. We addressed the hypothesis that porin interacts with other mitochondrial proteins after ischemic injury. Mater...

Despite recent improvements in treatment, ovarian cancer is still the leading cause of death from gynaecological malignancies. Today, marine mollusks are considered as natural source of new biologically and pharmacologically active compounds by scientists and the pharmaceutical industries. The aim of this study is to investigate the selective apoptotic effects of Turbo coronatus crude extract f...

Abstract Mycobacterium tuberculosis contains diverse immunologically active components. This study investigated the biological function of a newly identified component, Rv1654, with potential to induce apoptosis in macrophages. Recombinant Rv1654 induced macrophage caspase‐9/3‐dependent manner through production reactive oxygen species (ROS) and interaction Toll‐like receptor 4. In addition, tu...