Taxol (paclitaxel, PAC) is a diterpene with antitumor activity against a variety of human neoplasms. PAC cytotoxicity is thought to derive mainly from a stabilization of microtubules as a result of enhanced tubulin polymerization that leads to an accumulation of cells in G2/M phase of cell cycle. In this study, the cytotoxic effect occurred by PAC in tumor cells in vitro were examined. Mouse ma...

In this study, the antiproliferative effects of the metformin was evaluated on MCF-7 Cells (human breast adenocarcinoma cell line). For this purpose cell kinetic parameters including cell proliferation assay, mitotic index and labelling index analysis were used. 30 μM, 65 μM and 130 μM Metformin doses were applied to cells for 24, 48 and 72 hours. The results showed that there was a significant...

In this work, the cytotoxic and genotoxic influences of oxyfluorfen herbicide were surveyed by examining mitotic index, stages, chromosomal anomalies, micronucleus percentage, comet assay parameters on somatic cells Allium cepa. The roots treated with 0.2, 0.4, 0.8 1.6 ppm concentrations 12, 24 36 h. application periods. Mitotic index was noticeably diminished in each group when matched their c...

Proliferative activity of background and neoplastic colonie mucosa was examined following five months of weekly injec tions of 1,2-dimethylhydrazine (20 mg/kg) and one or four months of rest to determine whether previously reported changes may result from an acute or chronic effect of dimethylhydrazine and whether differences exist between stages of neoplasia. To determine whether neoplasia is ...

Oestrogen is a powerful mitogen that is believed to exert a continuous, dose-dependent trophic stimulus at the anterior pituitary. This persistent mitotic effect contrasts with corticosterone and testosterone, changes in the levels of which induce only transient, self-limiting fluctuations in pituitary mitotic activity. To further define the putative long-term trophic effects of oestrogen, we h...

The present study investigated the effect of zinc-deficiency on chromosomal abnormalities and mitotic index, interaction zinc deficiency methotrexate. Therefore, two zinc-deficient zinc-adequate diet received mice groups were constituted. Methotrexate was injected to one groups. There no structural numerical abnonnalities in all However, index significantly lower than other methotrexate adminis...

Gastrointestinal stromal tumors (GISTs) account for approximately 2% of gastric cancers and can be challenging to diagnose due to the difficulty sampling tissue from these lesions. Current biopsy methods are inadequate for determining the mitotic index, a major prognostic factor of these tumors. We sought to evaluate the ability of a prototype submucosal biopsy forceps to make a histologic diag...

OBJECTIVE We aimed to review our archives in order to evaluate both the diagnostic and prognostic significance of DOG1 on gastrointestinal stromal tumors (GISTs), and add further insight about those issues to the current literature including some conflicting results. MATERIAL AND METHOD DOG1 was evaluated in 100 cases of GISTs, immunohistochemically. Immunostaining index was counted for each ...

Background Due to the extremely rare incidence, data of clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumors (GISTs) are limited. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of mesenteric GISTs.Patients and Methods Mesenteric GISTs cases were obtained from our center and from case reports and clini...