Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs' permeation through the intestinal membrane has not been studied. The purpose of this work was to investigate the solubility-permeability interplay...

Abstract Objectives The main aim of the research was to analyze an economical and eco-friendly approach improve solubility norfloxacin. current analysis utilize hydrotropic solutions extract drugs from their dosage forms, avoiding use costlier harmful organic solvents. Materials Methods In this study, ultraviolet–visible spectrophotometer (model 1800, Shimadzu Corporation) used norfloxacin drug...

Based on the large number experiments on solubilization of poorly watersoluble drugs, the author is of the opinion that hydrotropy is another type of cosolvency and all water soluble substances whether solids, liquids or gases have solubilizing properties. Therefore, aqueous solutions containing small quantities of several water-soluble excipients giving a concentrated solution, may act as a so...

The present study demonstrates the use of mixed co solvency in the enhancement of solubility and estimation of ketoprofen, practically water insoluble dug and thus precludes the use of organic solvents. The selected solubilizers were sodium citrate (15%), PEG 400 (8%) and polyvinyl pyrolidine (7%). Beer’s law was obeyed in the concentration range of 2-20μg/ml at wavelength of 256nm. The solubil...

Abstract: Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs that are only sparingly soluble. Hydrotropy may be a distinctive development reinforce liquid poorly water-soluble drugs. Materials and Methods: The term hydrotropic has been wont designate rise in assorted substances water because presence enormous amounts additives. Sodium salicylate, sodiu...