This supplement contains extended versions of a selected subset of papers presented at the workshop MLSB 2007, Machine Learning in Systems Biology, Evry, France, from September 24 to 25, 2007.

A novel erythromycin ribosome methylase gene, erm(44), that confers resistance to macrolide, lincosamide, and streptogramin B (MLSB) antibiotics was identified by whole-genome sequencing of the chromosome of Staphylococcus xylosus isolated from bovine mastitis milk. The erm(44) gene is preceded by a regulatory sequence that encodes two leader peptides responsible for the inducible expression of...

Erythromycin and clindamycin are major alternatives to βlactam antibiotics. Bacterial resistance to macrolide and lincosamide antibiotics is increasing worldwide. Erm genes express either constitutive macrolide, lincosamide streptogramin B resistance phenotype (cMLSB) or inducible phenotype (iMLSB) and msrA gene expresses (MSB) phenotype. The aim of this study was to determine the frequency of ...

Draft genome sequences of two Campylobacterales (Sulfurospirillum sp. strain SCADC and Sulfuricurvum sp. strain MLSB [Mildred Lake Settling Basin]) were obtained by taxonomic binning of metagenomes originating from an oil sands tailings pond. Both genomes contain soxABXYZ genes involved in sulfur oxidation, highlighting their potential roles in sulfur cycling in oil sands tailings ponds.

BACKGROUND Extension of sensory blockade after an epidural top-up in combined spinal epidural (CSE) anesthesia is partly attributed to compression of the dural sac by the injected volume. This study investigated whether a volume effect plays a significant role when administering an epidural top-up after an initial epidural loading dose and assessed the predictive value of different factors with...

Quinupristin-dalfopristin (Q-D) is an injectable streptogramin active against most gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). In experimental endocarditis, however, Q-D was less efficacious against MRSA isolates constitutively resistant to macrolide-lincosamide-streptogram B (CMLSB) than against MLSB-susceptible isolates. To circumvent this problem, w...

M ethicillin-resistant Staphylococcus aureus (MRSA) first emerged as nosocomial pathogens in the early 1960s are of great concern to public health and highly reported in human clinical samples (1). There are major international concerns about rising levels of MRSA and multi-drug resistant S. aureus owing to the difficulties of treating infections and the ease with which MRSA spreads within hosp...

background: macrolides, lincosamides and type b streptogramins (mlsb) are commonly used for the treatment of staphylococcal infections. inducible mlsb resistance (imlsb) cannot be identified by standard methods of antibiotic susceptibility testing. d-test appears to be a reliable indicator of imlsb strains. the aim of this study was to determine the prevalence of clindamycin resistance phenotyp...