Creatine kinase (CK; EC 2.7.3.2), although the most commonly measured enzyme for assessing disease activity in polymyositis, is not always a reliable indicator of the extent and severity of myositis. Recently, the CK-MM isoenzyme has been found to undergo post-synthetic modifications upon release into the serum, such that electrophoretically identifiable sub-bands or subisoenzymes--MM1, MM2, an...

Pneumococcal prophages are extremely frequent, but no role in pathogenesis has so far been attributed to them. We isolated a variant of phage MM1, named MM1-1998, from a serotype 24 strain of Streptococcus pneumoniae. We created three isogenic strain pairs (serotypes 3, 4, and 24) that differed only by the lysogenic presence of the MM1-1998 phage and did a phenotypic comparison. Lysogeny led to...

The abundant presence of temperate phages in the chromosomes of clinical isolates of Streptococcus pneumoniae has been well documented. The genome of MM1, a temperate phage of pneumococcus, has been isolated as a DNA-protein complex. The protein is covalently bound to the DNA, was iodinated in vitro with Na125I, and has an Mr of 22,000. Electron microscopy and enzymatic analyses revealed that t...

This paper analyzes an M/M/2 queueing system with two heterogeneous servers. Both servers goes on vacation when there is no customers waiting for service after this server 1 is always available but the other goes on vacation whenever server 2 is idle. The vacationing server however, returns to serve at a low rate as an arrival finds the other server busy. The system is analyzed in the steady st...

Adhesion of tumor cells to host cell layers and subsequent migration are pivotal steps in cancer invasion and metastasis. The small GTP-binding protein RhoA controls cell adhesion and motility through organization of the actin cytoskeleton and regulation of actomyosin contractility. Cultured rat MM1 hepatoma cells migrate through a mesothelial cell monolayer in vitro in a serum-dependent, RhoA-...

a two server queueing system with single and batch service is considered in this paper. the arrival process is assumed to be poisson and the service rate follows an exponential distribution. server-i serves the customers in both single and batch service, while server-ii serves the customers in batch service only. the laplace transform of the transient and steady state behavior of the model is c...

An M/M/1 queueing system with second optional service and unreliable server is studied. We consider that the server works at different rate rather than being idle during the vacation period. The customers arrive to the system according to Poisson process with state dependent rates depending upon the server’s status. All customers demand the first essential service whereas only some of them dema...