Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving tablet. As the tablet surface composition and structure can change during dissolution, it is essential to monitor it during dissolution testing. I...

Proton transfer to the sulfa drug sulfadiazine [systematic name: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide] gave eight salt forms. These are the monohydrate and methanol hemisolvate forms of the chloride (2-{[(4-azaniumylphenyl)sulfonyl]azanidyl}pyrimidin-1-ium chloride monohydrate, C(10)H(11)N(4)O(2)S(+) · Cl(-) · H2O, (I), and 2-{[(4-azaniumylphenyl)sulfonyl]azanidyl}pyrimidin-1-ium chlori...

Background: Environmental problems of the plastic materials used in food packaging and the demand for food quality improvements lead to the development of packaging in natural materials. Edible films such as calcium alginate extend the shelf life by acting as a selective barrier against moisture and oxygen. The main objective of this study was to explore a calcium alginate based edible film to ...

Structural analysis of atherosclerotic coronary arteries has suggested that stress concentrations are associated with plaque rupture and that these stress concentrations are critically dependent on the geometry and mechanical properties of the fibrous cap and lipid pool. Recent clinical trials of lipid-lowering therapy have shown a significant reduction in cardiac events associated with plaque ...

Citation: Yu Z, Song F, Jin Y-C, Zhang W-M, Zhang Y, Liu E-J, Zhou D, Bi L-L, Yang Q, Li H, Zhang B-L and Wang S-W (2018) Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats. Front. Pharmacol. 9:328. doi: 10.3389/fphar.2018.00328 Comparative Pharmacokinetics of Gallic Acid After Oral Admin...

Aggregation behaviour of cefprozil monohydrate (C18H19N3O5S.H2O), an antibiotic, has been studied in presence of sodium dodecyl sulphate (SDS) and Cetyltrimethylammonium bromide (CTAB). Critical micelle concentration (CMC) of drug is determined to be 0.34 mM and is observed to decrease significantly at SDS < 2 mM. Above this concentration increase is less prominent and remains almost constant. ...

Carbon nanospheres (CNSs) and multi-walled carbon nanotubes (MWCNTs) as nanoadditives were used to modify lithium hydroxide monohydrate for low temperature chemical heat storage application. The lithium hydroxide monohydrate particles were well dispersed on the nanoscale level, and the diameter of nanoparticles was about 20–30 nm in the case of the carbon nanospheres and 50–100 nm the case of t...

We report a case of a heretofore healthy 18-year-old man who presented with a 2-day history of nausea, vomiting and stomach ache while taking creatine monohydrate for bodybuilding purposes. The patient had acute renal failure, and a renal biopsy was performed to determine the cause of increased creatinine and proteinuria. The biopsy showed acute tubular necrosis. In the literature, creatine mon...

An X-ray and a theoretical study of the structure of the isoniazid derivative N'-(4-dimethylaminobenzylidene)-isonicotinohydrazide monohydrate (1) are reported. In this work, we will report a combined experimental and theoretical study on the molecular structure, vibrational spectra and energies of N'-(4-dimethylaminobenzylidene)-isonicotinohydrazide monohydrate. The calculated parameters are i...