Using the peroxidase antiperoxidase (PAP) method, lysozyme (LZM) was shown to exist in normal, reactive and neoplastic cells belonging to the mononuclear phagocyte system (MPS), but was not detected in histiocytosis X cells. Immunostaining for cytoplasmic LZM by the PAP method is useful for identification of mononuclear phagocytes and for diagnosis of the diseases in which these cells participate.

Peyer's patches (PPs) are primary inductive sites of mucosal immunity. The PP mononuclear phagocyte system, which encompasses both dendritic cells (DCs) and macrophages, is essential for the initiation of the mucosal immune response. We recently developed a method to isolate each mononuclear phagocyte subset of PP (Bonnardel et al., 2015). We performed a transcriptional analysis of three of the...

Mononuclear-phagocyte system plays an important role in natural immunity and nonspecific resistance reactions of the organism against infection. The experimental studies using conventional laboratory animals with uncontrolled microflora have certain limitations to fully appreciate the role of autoflora (microbiota) in both development and functional activity of mononuclear-phagocyte system. In ...

Langerhans cell histiocytosis (LCH) belongs to histiocytic proliferative diseases, which are rare in clinical practice; however they pose significant challenges both for their diagnosis and choice of therapeutic strategies. Histiocytic diseases the scope oncology; nevertheless, at diagnostic stage patients referred pediatricians or dermatologists. That is why interdisciplinary interaction vario...