Background: Osteoarthritis is a degenerative joint disease lacking disease-modifying therapeutic agents. This study aimed to compare the effects of palm tocotrienol-rich fraction (TRF), glucosamine sulphate, and both agents combined in rats with osteoarthritis induced by monosodium iodoacetate (MIA). Methods: Thirty adult male were randomized into normal control, groups treated orally daily veh...

The animals with osteoarthritis suffer from clinical signs such as joint pain, reluctance to move, loss of performance and lameness. Many medical interventional methods are used manage but no described treatment can completely repair damaged cartilage yet. In this study, 40 male Wistar Albino rats were randomly assigned microfracture technique group, intra-articular hyaluronic acid + group cont...