Renal fibrosis poses critical health problem. We aimed to investigate role of let-7i-5p in renal fibrosis. In silico reproduction Mouse Kidney FibrOmics browser was used identify potential target let-7i-5p. vivo validation conducted C57BL/6 mice with unilateral ureteral obstruction (UUO) and folic acid (FA) induction. vitro performed transforming growth factor (TGF)-β1-treated HK-2 cells. Mimic...

Codiaeum variegatum has been widely investigated for its biological proprieties ranging from the antiamoebic potential to phytochemical analysis. The aim of present study was evaluate anti-inflammatory C. leaf extracts and fractions. A primary macrophage culture activated by Saccharomyces cereviseae (SC) used cell cytotoxicity plant Macrophages were treated with different concentrations (0.1; 1...

Many species of tea (Camellia sinensis) and cowslip (Echium amoenum) are used in Iranian traditional medicine. The aim of this study was to conduct the survey on the ability of Iranian black tea and cowslip extracts on secretion of tumor necrosis factor-alpha (TNF-alpha) by non-infected and infected mouse macrophages. A macrophage infection model with Legionella pneumophila and enzyme linked im...

Staphylococcus aureus is the leading cause of skin and soft tissue infections has become a major health burden due to emergence antibiotic-resistant strains. Tumor necrosis factor (TNF) proinflammatory cytokine that rapidly induced upon S. exposure whose inhibition associated with increased risk in humans. However, contribution TNF cognate receptors, TNFR1 TNFR2, host defense against unclear. T...

This study will examine the relationship between tumor necrosis factor (TNF) and intestinal mucosal injury in a cancer cachexia mouse model. The C26 adenocarcinoma cancer model was set up, and immunohistochemistry was performed to investigate the histological chances of injuring the intestinal mucosa and the intestinal villi. The liquid-phase protein chip was employed to examine the changes in ...

One intraperitoneal dose of Candida albicans (10(8) CFU) caused a chronic (longer than 2 months), significant elevation of plasma fibrinogen levels (Clauss method) in mice of strain C3H/HeN. Even a small dose (10(6) CFU) resulted in a significant increase in fibrinogen level for 5 days following injection, whereas other blood parameters (leukocytes, erythrocytes, platelets, hematocrit, hemoglob...

The sea star Asterias rubens includes TNFR, in its genome, when compared to mouse one: mouse isoform 2 of TNF AIP3-interacting protein 1, mouse TNF receptor-associated factor 2, mouse TNF receptor-associated factor 3, mouse TNF receptor-associated factor 4, mouse TNF receptor-associated factor 6. Many of these factors are bound to NF Kappa -B genes which have recently been isolated in the Aster...

Human cell lines of hematopoietic origin were tested for production of tumor necrosis factor (TNF). B-cell lines transformed by Epstein-Barr virus release a factor (referred to as hTNF) that is cytotoxic for mouse L cells sensitive to mouse TNF but not for L cells resistant to mouse TNF. Exposure to 4 beta-phorbol 12 beta-myristate 13 alpha-acetate augmented production of hTNF. hTNF activity wa...

We have distinguished five TNF-alpha-inducible cell adhesion mechanisms on microvasculature-derived endothelioma cells of the mouse which mediate the binding of different types of leukocytes. Three of these mechanisms could be identified as the mouse homologs of ICAM-1, VCAM-1, and E-selectin, of which the latter was defined by the novel mAb 21KC10. The fourth TNF-alpha-inducible cell adhesion ...

Tumor necrosis factor a/cachectin (TNF/C) is a well-characterized peptide (1) that may, through its diverse effects on cells, mediate many normal host functions, including tissue remodeling and the mobilization of energy reserves required by the infected host (2). In contrast to such beneficial effects, TNF/C has also been shown to have adverse effects on the animal host . It is a principal med...