OBJECTIVES To evaluate the activity of a new cephalosporin, ceftaroline, in comparison with other antistaphylococcal drugs (linezolid and vancomycin) at projected human therapeutic doses against methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-intermediate S. aureus (GISA) strains. METHODS Using a rabbit experimental model of acute osteomyelitis, efficacy was assessed follo...

OBJECTIVES The aim of this study was to assess the in vitro activities of nemonoxacin against Gram-positive cocci with various resistance phenotypes. METHODS MICs of nemonoxacin were determined for 798 recently collected (2005-07) and non-duplicate isolates of Gram-positive cocci by the agar dilution method. These isolates included: methicillin-susceptible Staphylococcus aureus (MSSA; n = 100...

We evaluated the activity of ceftobiprole against 100 community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and 100 hospital-associated MRSA (HA-MRSA) isolates. Eight isolates were evaluated by time-kill studies for kill rate and potential for synergy with tobramycin. Ceftobiprole MIC(50) and MIC(90) values were 1 and 2 microg/ml, respectively, against CA-MRSA and HA-MRSA. ...

Introduction: Aloe Vera compounds have inhibitory activity on fungi, bacteria, and viruses. This study examines the antibacterial activity of A. Vera purified extracts including gel, boiled skin, boiled gel, and distilled extract against pathogenic bacteria, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Klebsiella pneumonia and Pseudomonas aeruginosa were elucidated. Method: Th...

Marine Streptomyces sp.VITBRK3 isolated from the sediment sample collectedat the Marakkanamcoast located in the Southeast coastal region of Bay of Bengal, India. The ethyl acetate extract was prepared from the culture supernatant of Streptomyces sp.VITBRK3.The anti-MRSA compound was purified by silica gel column chromatography and HPLC. The purified compound was identified by using H and C NMR ...

BACKGROUND AND OBJECTIVES Methicillin-resistant Staphylococcus aureus (MRSA) infections are a rapidly growing health problem around the globe. Recently, there has been considerable interest in the use of plant materials as an alternative method to control pathogenic microorganisms. In this study we evaluated the antibacterial activity of bark of Alnus pendula against MRSA. MATERIALS AND METHO...

BACKGROUND Worldwide, methicillin-resistant Staphylococcus aureus (MRSA) rates have increased dramatically during the last decades. Sodium benzoate (SB) is a chemical substance that is used for preparing food and drinks and in the treatment of some metabolic (urea cycle disorders and hepatic coma) diseases. No studies were found which focussed on the effects of SB in MRSA infections. The aim wa...

The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a growing cause for concern. These strains are more virulent than health care-associated MRSA (HA-MRSA) due to higher levels of toxin expression. In a previous study, we showed that the high-level expression of PBP2a, the alternative penicillin binding protein encoded by the mecA gene on type II staph...

This study investigated the potential antibacterial activity of three series of compounds synthesized from 12 linear and branched polyamines with 2-8 amino groups, which were substituted to produce the corresponding guanides, biguanides, or phenylguanides, against Acinetobacter baumannii, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Antibacterial ac...

A previously unknown pH-effect on the antimicrobial activity of peptide dendrimers and polymyxin B against Klebsiella pneumoniae MRSA is reported.