MR spectroscopic imaging (MRSI) has become widely available as a research tool for mapping tissue metabolic status. Clinical research applications have been limited by intrinsically low sensitivity and by time-consuming phase encoding techniques that are used with conventional MRSI. The long encoding times limit volume coverage, introduce motion sensitivity and tax patient tolerance. The increa...

A novel nuisance removal method is proposed for 1H-MRSI. The method uses spectral bases generated for water and subcutaneous lipids using quantum simulation, and can perform nuisance signal removal directly from (k,t)-space data. Consequently, the proposed method is able to handle sparsely sampled MRSI data, which provides a desirable flexibility for designing accelerated 1H-MRSI data acquisiti...

Background: For the purpose of individual clinical target volume assessment in radiotherapy of prostate cancer, MRSI was used as a molecular imaging modality with MRI and CT images. Materials and Methods: The images of 20 prostate cancer patients were used in this study. The MR and MRSI images were registered with CT ones using non-rigid registration technique. The CT based planning (BP), CT/MR...

We used proton magnetic resonance spectroscopic imaging (MRSI) to assess in vivo cortical neuronal involvement in hyperekplexia. Cerebral neuronal function was measured using proton MRSI in four unrelated patients with hyperekplexia and 20 healthy controls. All patients had the major form of hyperekplexia, with additional atypical clinical features in two of them. Family history was positive in...

AIM To assess the relationship using multimodality imaging between intermediary citrate/choline metabolism as seen on proton magnetic resonance spectroscopic imaging (1H-MRSI) and glycolysis as observed on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in prostate cancer (PCa) patients. METHODS The study included 22 patients with local PCa who were re...

INTRODUCTION Low SNR of proton magnetic resonance spectroscopic imaging (MRSI) in vivo data for a small voxel size (e.g., 0.4cc) necessitates multiple-average acquisition that leads to a long scan time. This issue is even more pronounced when one attempts to acquire J-resolved spectroscopic data using multi-echo acquisition [3] in order to resolve metabolite concentrations such as glutamate and...

AIM To compare the prostate antigen 3 (PCA3) test with (1)H-magnetic resonance spectroscopic imaging ((1)H-MRSI) and dynamic contrast-enhanced magnetic resonance imaging (DCEMR) combined examination in the detection of prostate tumor foci in patients with persistently elevated prostate-specific antigen (PSA) levels and prior negative random transrectal ultrasound (TRUS)-guided biopsy. PATIENT...

Proton magnetic resonance spectroscopic imaging (H-MRSI) provides noninvasive information regarding metabolic activity within the tissues. One of the main problems of MRSI is low spatial resolution due to clinical scan time limitations. Advanced post-processsing algorithms, like convolutional neural networks (CNN) might help with generation of super resolution MR spectroscopic images. In this s...

The advantages of using a 3 Tesla (T) scanner for MR spectroscopic imaging (MRSI) of brain tissue include improved spectral resolution and increased sensitivity. Very selective saturation (VSS) pulses are important for maximizing selectivity for PRESS MRSI and minimizing chemical shift misregistration by saturating signals from outside the selected region. Although three-dimensional (3D) PRESS ...

This work presents a new approach for high-resolution MRSI of the brain at 7 T in clinically feasible measurement times. Two major problems of MRSI are the long scan times for large matrix sizes and the possible spectral contamination by the transcranial lipid signal. We propose a combination of free induction decay (FID)-MRSI with a short acquisition delay and acceleration via in-plane two-dim...