Although the regulation of mitochondrial DNA (mtDNA) copy number is performed by nuclear-coded factors, very little is known about the mechanisms controlling this process. We attempted to introduce nonhuman ape mtDNA into human cells harboring either no mtDNA or mutated mtDNAs (partial deletion and tRNA gene point mutation). Unexpectedly, only cells containing no mtDNA could be repopulated with...

results the relative expression of mtdna copy number was 3.7 fold higher in nafld patients than healthy controls (p < 0.0001). the results remained significant after adjustment for age, bmi, and gender (p = 0.02). in addition, the mtdna copy number was 4.3 (p < 0.0001) and 3.2-fold (p < 0.0001) higher in nonalcoholic fatty liver (nafl) and non-alcoholic steatohepatitis (nash) patients than heal...

Coastal common bottlenose dolphins show a variety of migration and residency patterns adding to the difficulty defining stocks for management purposes. Genetic structure plays an important role in identifying population dolphins. This study examines genetic differentiation both between two social groups occurring Biscayne Bay, Florida Bay adjacent group Bay. Skin biopsy samples were sequenced a...

The yeast mitochondrial chaperonin Hsp60 has previously been implicated in mitochondrial DNA (mtDNA) transactions: it is found in mtDNA nucleoids associated with single-stranded DNA; it binds preferentially to the template strand of active mtDNA ori sequences in vitro; and wild-type (rho+) mtDNA is unstable in hsp60 temperature-sensitive (ts) mutants grown at the permissive temperature. Here we...

Mitochondrial DNA (mtDNA) mutations can result in mitochondrial dysfunction, but emerging experimental data question the fundamental role of mtDNA mutagenesis in age-associated mitochondrial impairment. The multicopy nature of mtDNA renders the impact of a given mtDNA mutation unpredictable. In this study, we compared mtDNA stability and mtRNA integrity during normal aging. Seven distinct sites...

The objectives this year have been to model the features of a CZ which we observed in the PhilSea09 experiment. The data from this found very abrupt transitions and into the CZ’s and narrow widths for them. We note that not all CZ’s ”focus”, i.e. sharp edges as we observed in the Philippine Sea. This feature has been noted by Brekhovskikh and Munk where they noted that such zones tend to remain...

Chenxi Li,a, b Xueming Luo,c Cheng Zhang,b, * Xiaoyi Wangd a School of Economics and Management, Beihang University, 100191 Beijing, China; b School of Management, Fudan University, 200433 Shanghai, China; cFox School of Business, Temple University, Philadelphia, Pennsylvania 19122; d School of Management, Zhejiang University, 310058 Hangzhou, China *Corresponding author Contact: chenxili@buaa....