Activation of mTOR is implicated in the development and progression of breast cancer. mTOR inhibition exhibited promising antitumor effects in breast cancer; however, its effect is compromised by several feedback mechanisms. One of such mechanisms is the upregulation of mTOR pathway in breast cancer cells. Despite the established role of mTOR activation in breast cancer, the status of total mTO...

As a critical regulator of cell growth, the mechanistic target of rapamycin (mTOR) protein operates as part of two molecularly and functionally distinct complexes. Herein, we demonstrate that mTOR complex molecular composition varies in different somatic tissues. In astrocytes and neural stem cells, we identified G-protein-coupled receptor kinase-interacting protein 1 (GIT1) as a novel mTOR-bin...

Cancer is a multifactorial disease that continues to increase. Lignans are known be important anticancer agents. However, due the structural diversity of lignans, it difficult associate activity with particular subclass. Therefore, present study sought evaluate association lignan subclasses antitumor activity, considering genetic profile variants selected targets. To do so, predictive models we...

Posterior capsule opacification (PCO) is the most common complication that causes visual decrease after extracapsular cataract surgery. The primary cause of PCO formation is the proliferation of the residual lens epithelial cells (LECs). The mammalian target of rapamycin (mTOR) plays an important role in the growth and migration of LECs. In the current study, we used small interfering RNA (siRN...

Introduction . Current chemotherapy of breast cancer has a wide range disadvantages, in particular, the development therapy-related infections and hormonal imbalance. Combination main cytostatic with glucocorticoids allows to broaden its therapeutic interval decrease total toxicity treatment. However, long-term treatment leads severe side effects via activation multiple molecular mechanisms. Th...

The mammalian target of rapamycin (mTOR) controls cell growth in response to amino acids and growth factors, in part by regulating p70 S6 kinase alpha (p70 alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor (regulatory associated protein of mTOR) is a 150 kDa mTOR binding protein that is essential for TOR signaling in vivo and also binds 4EBP1 and p70alpha through thei...

Sepsis and lipopolysaccharide (LPS) may decrease skeletal muscle protein synthesis by impairing mTOR (mammalian target of rapamycin) activity. The role of mTOR in regulating muscle protein synthesis was assessed in wild-type (WT) and mTOR heterozygous (+/-) mice under basal conditions and in response to LPS and/or leucine stimulation. No difference in body weight of mTOR(+/-) mice was observed ...

The altered expression and activation of the mammalian target of rapamycin (mTOR) promotes the invasiveness and metastatic potential in a variety of malignancies. The aim of the present pilot study was to determine mTOR expression in clear cell renal cell carcinoma (RCC) and to evaluate mTOR activation and phosphorylation at Ser2448. Tissue microarray immunohistochemistry and Western blot analy...