background and objectives: the etiology, pathophysiology, nomenclature and clinical manifes-tation of solitary rectal ulcer syndrome (srus) is poorly understood. aim: to examine the pathology of mucosal changes and clinical features of this syndrome. materials and methods: the mucosal biopsies of 19 patients with clinical evidence of solitary rectal ulcer as been reviewed in accordance with the...

A group of autoimmune diseases is characterised by autoantibodies against epithelial adhesion structures and/or tissue-tropic lymphocytes driving inflammatory processes resulting in specific pathology at the mucosal surfaces and the skin. The most frequent site of mucosal involvement in autoimmune diseases is the oral cavity. Broadly, these diseases include conditions affecting the cell-cell ad...

Pemphigus is a group of potentially life-threatening autoimmune diseases characterized by cutaneous and/or mucosal blistering. Pemphigus vulgaris (PV), the most common variant, is characterized by circulating IgG antibodies directed against desmoglein 3 (Dsg3), with about half the patients also having Dsg1 autoantibodies.There is a fairly strong genetic background to pemphigus with linkage to H...

Diseases and symptoms of mouth mucosa are prevalent in particular in the ageing populations. For example, a nationwide representative examination in the US revealed approximately 28% prevalence of all oral mucosal lesions in subjects 17 years of age and older with distinct differences between age groups and whether or not the subject smoked [27]. There are no comprehensive epidemiological data ...

Background: The oral cavity is a unique environment where systemic maladies may be amplified by the oral mucosa. Sometimes, oral lesions are the first indication of a systemic problem. Oral mucosal lesions may be the initial feature or the only clinical sign of mucocutaneous diseases commonly observed in a dermatologic practice. Aim and Objectives: To assess the frequency of the oral manifestat...