Combining two or more different imaging modalities in the same agent can be of considerable value in molecular imaging. We describe the use of streptavidin nanoparticle-based complexes as multimodality imaging agents to achieve tumor detection in a mouse model by both fluorescence and nuclear imaging. Up to four biotinylated functionalities can be readily attached to these streptavidin nanopart...

abstract hypoplastic right ventricular is a rare congenital heart disease. a few cases have been reported. we presented a case with hypoplastic right ventricular and multiple associated anomaly (ventricular septal defect, atrial septal defect and pulmonary stenosis) in whom the main concern was whether biventricular repair or fontan type surgery would be the optimal management in this patient. ...

Transcatheter aortic valve replacement is a major advance that has dramatically changed our approach to elderly patients with severe aortic stenosis. This advance has been made possible by innovative device and delivery improvements, coupled with rapid developments in multimodality imaging. Multimodality imaging draws from multiple imaging fields and is central to patient evaluation and treatme...

Angiogenesis is an important biological process that is also related to various diseases, such as cancer, cardiovascular and cerebrovascular disease. Currently, the need for angiogenesis imaging is increasing due to the use of anti-angiogenic therapy to treat tumors, and of angiogenesis-inducing therapy to treat vascular diseases. Several techniques can be used to visualize angiogenesis related...

Noninvasive “multimodal” in vivo imaging is not just becoming standard practice in the clinic, but is rapidly changing the evolving field of experimental imaging of genetic expression (“molecular imaging”). The development of multimodality methodology based on nuclear medicine (NM), positron emission tomography (PET) imaging, magnetic resonance imaging (MRI), and optical imaging is the single b...

Molecular imaging using high-resolution PET instrumentation has a pivotal role in basic and clinical research. The development of optimized detection geometries combined with high-performance detector technologies and compact designs of PET tomographs has become the goal of active research groups in academic and corporate settings. More recently, the introduction of dual-modality PET/CT imaging...