OBJECTIVE To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases. DATA SOURCES Published studies and scientific paper presentations. STUDY SELECTION Randomized clinical studies and retrospective reviews. CONCLUSIONS S...

Surgical treatment of cancer of the esophagus is influenced by two issues: use of surgical resection within a multimodality treatment approach and selection of the correct surgical approach. Selecting the correct surgical approach should be individualized and determined by the intent of surgery (curative or palliative), the anatomic location of the tumor (cervical or thoracic), the preferred me...

MEK MEK162 GDC-0973 GSK1120212 MSC1936369B STAT3 OPB51602 AKT MK2206 Stage a Est. % General treatment recommendations 5-year overall survival b clinical stage path. stage IA 14% Surgical resection 50% 73% IB 10% Surgical resection, can consider adjuvant chemotherapy in selected cases (e.g. tumor size > 4cm) 43% 58% IIA 6% Surgical resection followed by adjuvant chemotherapy 36% 46% IIB 5% Surgi...