Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) which causes demyelination of the nerve fibers. The etiology of this disease is not well understood but it is believed that T helpers play a central role in MS. Numerous findings support the view that Th17 cells play an essential role in pathogenesis of MS and IL-17 secreting T (Th17) cells have a role in infla...

background coronary artery diseases (cad) are associated with psychological problems such as anxiety and depression in patients. thus, management of these problems can consider as an important intervention by health care workers, especially nurses. objectives the purpose of this study was to investigate the effectiveness of patient-focused clinical pathway on anxiety, depression and satisfactio...

Signaling pathways are an ever present force in every animal’s life. During development, these pathways provide critical cell-cell communication required to coordinate the activities of vast numbers of cells. In adulthood, similar communication mechanisms are utilized to achieve tissue homeostasis and regeneration. Regulation of signaling is crucial; toomuch or too little activity from a given ...