نتایج جستجو برای: multipotent
تعداد نتایج: 4785 فیلتر نتایج به سال:
Whether cortical projection neurons (CPNs) are generated by multipotent or fate-restricted progenitors is not completely understood. In this issue of Neuron, Guo et al. (2013) provide evidence that mouse Fezf2-expressing radial glial cells are multipotent progenitors that sequentially generate all major CPN subtypes and glia.
Mesenchymal stem cells (MSCs) or adult multipotent progenitor with the ability to self-renew and differentiate, are extracted from a variety of tissues, including bone marrow, adipose tissue, umbilical cord blood, Wharton’s jelly, tooth pulp, menstrual others. Since they multipotent, cultured MSCs can differentiate into adipogenic, chondrogenic, osteogenic lineages after being isolated. Due the...
Mast cells are bone marrow derived hemopoietic (Kitamura, et al. [1-3]). The mast cell is one of the important in immune system. It from multipotent hematopoietic progenitor cells. produces a number cytokines to augment responses, growth, and differentiation other
Although neurogenesis continues throughout life in the mammalian brain, the issue of whether the stem cells that drive the process in vivo are self-renewing and multipotent remains unclear. In a recent landmark paper by Bonaguidi et al. (2011) published in Cell, the authors provide clonal evidence that neural stem cells in the dentate gyrus of the adult hippocampus are indeed multipotent and un...
In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become increasingly restricted in their differentiation potential through oligopotent and then unipotent progenitors. We developed a cell-sorting scheme to resolve myeloid (My), erythroid (Er), and megakaryocytic (Mk) fates from single CD34(+) cells and...
The multipotent hemopoietic stem cell has fastidious growth requirements in vitro. Traditionally, phytohemagglutinin-stimulated leukocyte conditioned medium has been used to supply the undefined growth factors required for culture of the human multipotent hemopoietic progenitor. We describe the use of medium conditioned by the bladder carcinoma cell line, 5637, to replace PHA-LCM in CFU-GEMM cu...
Emergence of hemopoietic stem cells in the mammalian embryo has yet to be definitively allocated. Previously, we detected multipotent hemopoietic precursors in the region surrounding the dorsal aorta (paraaortic splanchnopleura) beginning at 8.5 days postcoitum (dpc). However, as circulation is already established, it remained unclear whether hemopoietic precursors arise in situ or are blood-de...
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal.
Neural stem cells (NSCs) in the postnatal mammalian brain self-renew and are a source of neurons and glia. To date, little is known about the molecular and cellular mechanisms regulating the maintenance and differentiation of these multipotent progenitors. We show that Jagged1 is required by mitotic cells in the subventricular zone (SVZ) and stimulates self-renewal of multipotent epidermal grow...
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