Existing multispectral imagers mostly use available array sensors to separately measure 2D data slices in a 3D spatial-spectral data cube. Thus they suffer from low photon efficiency, limited spectrum range and high cost. To address these issues, we propose to conduct multispectral imaging using a single bucket detector, to take full advantage of its high sensitivity, wide spectrum range, low c...

Objective. Sentinel node biopsy in patients with cutaneous melanoma improves staging, provides prognostic information, and leads to an increased survival in node-positive patients. However, frozen section analysis of the sentinel node is not reliable and definitive histopathology evaluation requires days, preventing intraoperative decision-making and immediate therapy. Photoacoustic imaging can...

We describe a method for selecting filter sets for simultaneously optimizing the classification rates in two separate spectral signature classification problems. Our system’s performance is comparable to traditional hyper-or multispectral classifiers, but uses fewer filters. c © 2010 Optical Society of America OCIS codes: (110.1758) Computational imaging, (110.4234) Multispectral and hyperspect...

Accurate detection of mitosis plays a critical role in breast cancer histopathology. Manual detection and counting of mitosis is tedious and subject to considerable interand intra-reader variations. Multispectral imaging is a recent medical imaging technology, proven successful in increasing the segmentation accuracy in other fields. This study aims at improving the accuracy of mitosis detectio...

This paper presents an experimental investigation of the application of multispectral imaging in dermatology. The focus areas of this work are as follows: a) the improving the color reproduction accuracy of skin lesions, b) exploring the spectral feature of skin disease using the multispectral color enhancement technique, and c) multispectral image analysis aiming at supporting quantitative dia...

Fluorescence lifetime imaging microscopy (FLIM) offers a noninvasive approach for characterizing the biochemical composition of biological tissue. In recent years, there has been an increasing interest in the application of multispectral FLIM for medical diagnosis. Central to the clinical translation of FLIM technology is the development of robust, fast, and cost-effective FLIM instrumentation ...

Two promising technologies have been developed to improve image acquisition, namely high dynamic range (HDR) and multispectral imaging. In HDR imaging, several RGB images acquired with different exposures are combined into one image with greater dynamic range. This reduces saturated and underexposed image areas and improves the signal-to-noise ratio (SNR) of the image. On the other hand, multis...

An infrared (IR) multispectral imaging spectrometer is an instrument that can simultaneously record infrared spectroscopic and spatial information of a sample. Chemical and physical properties of the sample can be elucidated from such images. In a multispectral imaging instrument, a camera is used to record the spatial distribution of the sample, and the spectral information is obtained with a ...