Statins are commonly used drugs in the treatment of hyperlipidemia (HL), despite some undesirable side effects. These range from mild symptoms such as myopathy, muscle weakness and myalgia to severe muscle weakness associated with chronic myopathy and acute renal failure (ARF) as a result of rhabdomyolysis. The most serious and deadly side effect of statins is rhabdomyolysis. The case presente...

Muscle-tendon unit surgery for correction of deformities and movement dysfunction in children with cerebral palsy (CP) is fairly complicated. An understanding basic muscle-tendon properties their adaptation to both CP are important develop advances this field. In review, we provide information therapists, surgeons, scientists regarding the short- long-term adaptations unit. Surgical releases, l...

Transmission of signals from nerves to muscles is critical for life, so substantial safety factor mechanisms have evolved to ensure its success. Despite this, diseases can impair even this robust system. Characterizing these disease mechanisms greatly contributes to understanding this fundamental process. Neuromuscular transmission serves as a model for helping to understand neurotransmission t...

A ubiquitous, vitamin-D deficiency is still unrecognized a n d u n d e r d i a g n o s e d . P r o x i m a l m u s c l e w e a k n e s s i s a c o m m o n symptom of vitamin-D deficiency and occurs before biochemical signs of its deficiency appears. Therefore, vitamin-D deficiency should be kept in the differential diagnosis for the muscle weakness, as it is reversible and easily treated with v...

OBJECTIVE The objective of this study was to determine the pattern of muscle weakness in patients with Guillain-Barre Syndrome. METHODS In a cross-sectional study, 50 Iraqi patients aged one to 60 years diagnosed with Guillain-Barre Syndrome according to Asbury criteria, admitted in 5 Neurological Centers in Baghdad, Iraq between October 1997 and October 1999, were studied for pattern of musc...

• duchenne muscular dystrophy o onset 3 to 5 yrs o clinical § weakness o distribution § proximal > distal § symmetric § legs & arms § most involved muscles: adductor magnus in legs § relatively spared muscles: gracilis & sartorius o course § reduced motor function by 2 to 3 years § steady decline in strength: after 6 to 11 years o gowers sign: standing up with the aid of hands pushing on knees ...

In addition to the primary symptoms arising from inflammatory processes in the joints, muscle weakness is commonly reported by patients with rheumatoid arthritis (RA). Muscle weakness not only reduces the quality of life for the affected patients, but also dramatically increases the burden on society since patients' work ability decreases. A 25-70% reduction in muscular strength has been observ...

Two patients with muscle weakness caused by amyloid myopathy are described. Characteristic features such as pseudohypertrophy and abnormal firmness, and tumours of muscles were absent. It is suggested that muscle weakness in amyloid myopathy is caused by layers of amyloid covering muscle fibres. In middle aged or elderly patients with proximal muscle weakness the diagnosis of amyloid myopathy s...

idiopathic inflammatory myopathies are a heterogeneous group of muscle disorders characterized by chronic muscle inflammation and progressive muscle weakness. polymyositis (pm), dermatomyositis (dm) and inclusion body myositis (ibm) are the three major subsets based on distinct clinical and histopathological features. since the pathogenesis remains unclear, therapeutic approaches actually compr...