Behcet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Rheumatologic manifestations may also occur in Behcet's disease, and arthritis and arthralgia are the most common musculoskeletal findings followed by enthesopathy, avascular necrosis, myalgia, and m...

In 1985, Strom et al described two families in which rheumatoid arthritis (RA) appeared in several members over three consecutive generations.' Although these pedigrees taken alone could implicate dominant inheritance, the overall picture with RA pedigrees indicates a complex mode of inheritance, with incomplete penetrance of predisposing genes and probably several genes being involved in the d...

WHAT IS THE PROBLEM? Musculoskeletal disease is a common condition that affects up to one-quarter of the population over 65 years in many developed countries. Over 6 million Australians (1) and 27 million Americans (2) are affected by some type of musculoskeletal disorder of which osteoarthritis (OA) is the most common. Musculoskeletal disorders account for one-fifth of all consultations with g...

waste collection is a necessary activity all around the world and the removal of municipal solid waste is a job associated with a variety of biological, chemical, mechanical, physical, and psychosocial hazards. in our country, like many developing countries, municipal solid waste is collected manually and collection of household waste is also a job which requires repeated heavy physical activit...

Progranulin (PGRN) is a growth factor that has been implicated in wound healing, inflammation, infection, tumorigenesis, and is most known for its neuroprotective and proliferative properties in neurodegenerative disease. This pleiotropic growth factor has been found to be a key player and regulator of a diverse spectrum of multi-systemic functions. Its critical anti-inflammatory role in rheuma...