The structural requirements for the inhibitor activity of various furan carboxanilide derivatives against succinate dehydrogenase complex (SDC) activity in mitochondria of either wild or mutant strains of Ustilago maydis were investigated with the aid of Hansch QSAR analysis. It has been found that the inhibitor activity against both types of enzymes is best related to the ??? or ??M of th...

background: colibacillosis, caused by different serotypes of avian pathogenic escherichia coli (apec), is one of the important diseases in poultry industry. the isolate o78 is the most prevalent serotype of apec in iran. one of the apec virulence factors, increased serum survival (iss) gene, is related to serum resistance. the usual form of colibacillosis in avian is extraintestinal, and serum ...

this study was conducted to determine physiological and morphological variation of strains of the ectomycorrhizal fungus hebeloma cylindrosporum associated with pinus pinaster and its consequence on the symbiotic processes in coastal forests adjacent to bordeaux, south west france, from 2003-2005. mycelial cultures were conducted in the laboratory on a rich medium (ymg). diploid fungal strains ...

Underexpression of the transcriptional coactivator PGC-1α is causally linked to certain neurodegenerative disorders, including Huntington's Disease (HD). HD pathoprogression is also associated with aberrant NMDAR activity, in particular an imbalance between synaptic versus extrasynaptic (NMDAR(EX)) activity. Here we show that PGC-1α controls NMDAR(EX) activity in neurons and that its suppressio...

Carassius auratus var. pingxiangnensis is a natural triploid crucian carp mutant. In order to understand its placement and genetic background at the gene level, the characteristics of mitochondrial DNA sequences and phylogenetic relationship were examined. The results showed that the mitochondrial DNA is a circular double-stranded DNA molecule that is 16,576 bp in length with 13 protein-coding ...

HE mutant alleles of the dumpy locus produce a number of phenotypic Teffects, viz., an obliquity of the wings ( 0 ) , a lethal effect (1) , and hypodermal irregularities of the thorax called vortices (v) . The genetics of the dumpy locus has been described by CARLSON (1959). The alleles may express any one of the three effects singly (dp", d p z , dp") or in any combination with one another (dp...

In members of the family Enterobacteriaceae, ampC, which encodes a beta-lactamase, is regulated by an upstream, divergently transcribed gene, ampR. However, in Pseudomonas aeruginosa, the regulation of ampC is not understood. In this study, we compared the characteristics of a P. aeruginosa ampR mutant, PAOampR, with that of an isogenic ampR+ parent. The ampR mutation greatly altered AmpC produ...

The core domain of the tumour suppressor p53 is of inherently low thermodynamic stability and also low kinetic stability, which leads to rapid irreversible denaturation. Some oncogenic mutations of p53 act by just making the core domain thermosensitive, and so it is the target of novel anti-cancer drugs that bind to and stabilise the protein. Increasing the stability of the unstable core domain...

Huntingtin, the protein that when mutated causes Huntington disease (HD), has many known interactors and participates in diverse cellular functions. Mutant Htt (mHtt) engages in a variety of aberrant interactions that lead to pathological gain of toxic functions as well as loss of normal functions. The broad symptomatology of HD, including diminished voluntary motor control, cognitive decline, ...

The unconventional myosin genes Myo15, Myo6 and Myo7a are essential for hearing in both humans and mice. Despite the expression of each gene in multiple organs, mutations result in identifiable phenotypes only in auditory or ocular sensory organs. The pirouette (pi) mouse also exhibits deafness and an inner ear pathology resembling that of Myo15 mutant mice and thus may be functionally related ...