INTRODUCTION AND OBJECTIVES Several biomarkers have been used for evaluation and quantification of myocardial injury after effective ablation. We studied possible different thermal stability and usability of the proteins released by cardiac cells injured by different energy sources. METHODS Firstly, we tested in vitro thermal stability of creatinine kinase (CK), myocardial bound creatinine ki...

BACKGROUND Measurement of circulating biomarkers has enabled early diagnosis and risk assessment of acute coronary syndrome. This study sought diagnostic values of the first single-point data of biomarkers obtained soon after patient arrival by comparing with scintigraphically quantified myocardial injury in patients presenting with acute chest pain at an emergency room. METHODS AND RESULTS S...

Background Focal myocardial fibrosis is frequently observed in dilated cardiomyopathy (DCM) and predicts future major adverse cardiovascular events and patient outcome. However, the pathogenesis of fibrosis in DCM remains poorly understood. Novel serum biomarkers of fibrosis such as Endoglin have been recently identified as a trigger of myocardial fibrosis in heart failure. Accordingly, we soug...

Background: At present, acute myocardial infarction (AMI) is a serious cardiovascular disease with high morbidity and mortality. Discovering biomarkers of AMI important for clinical diagnosis needs. Therefore, this study aimed to elucidate the role XPNPEP3 as potential biomarker AMI.

The diagnosis and management of patients with acute coronary syndrome (ACS) have evolved dramatically over the past decade. Biomarkers play an important role in the diagnosis of ACS, especially in unstable angina and non-ST-segment elevation myocardial infarction. Among these, cardiac troponin and creatine kinase appear to be the most sensitive and specific markers of myocardial injury. Recent ...

Clinicians have become increasingly sophisticated in their application of cardiac biomarkers in the management of acute coronary syndromes (ACS). In the 1950s, clinical investigators first reported that proteins released from necrotic cardiac myocytes could be detected in the serum and could aid in the diagnosis of acute myocardial infarction.1 The ensuing 40 years witnessed progressive improve...

BACKGROUND MicroRNAs (MiRNA) are a novel class of non-coding RNAs involved in the regulation of gene expression post-transcriptionally by cleavage or translational repression of their specific target miRNAs. Numerous studies have demonstrated that circulating miRNAs are stable and abundant in blood and aberrantly expressed under pathological conditions, including cardiovascular diseases. The im...