Parameter estimation from non-invasive measurements is a crucial step in patient-specific cardiac modeling. It also has the potential to provide significant assistance in the clinical diagnosis of cardiac diseases through the quantification of myocardial material heterogeneity. In this paper, we formulate a novel Reduced-order Unscented Kalman Filter (rUKF) applied to the left ventricular (LV) ...

OBJECTIVES This study sought to examine the changes in ventricular function of hypoplastic left heart syndrome (HLHS) between the first 2 stages of surgical palliation. BACKGROUND The mortality risk between first and second stages of surgical palliation in HLHS remains high. Right ventricular (RV) dysfunction predicts mortality. Postulated mechanisms include a maladaptive contraction pattern,...

to investigate the cardioprotective potential of the aqueous extract of allium cepa linn. bulb in isoprenaline-induced myocardial injury in wistar albino rats. in vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. isoprenaline-induced myocardial injury model was used to evaluate in vivo effect of aqueous extract of...

Heart failure with preserved ejection fraction (HFPEF) is characterized by myocardial interstitial fibrosis. A total of 146 patients with HFPEF, were recruited. HFPEF severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). Canine modeling of HFPEF was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after...

Several surgical approaches are being used to induce myocardial ischemia in rats. The present study investigated two different operative procedures in spontaneously breathing and mechanically ventilated rats under sham conditions. A snare around the left coronary artery (LCA) was achieved without occlusion. Left lateral thoracotomy was performed in spontaneously breathing and mechanically venti...

OBJECTIVES Tension cost, the ratio of myosin ATPase activity to tension, reflects the economy of tension development in the myocardium. To evaluate the mechanical advantage represented by the tension cost, we studied papillary muscle contractility and the activity of myosin ATPase in the left ventricles in normal and pathophysiological conditions. METHODS Experimental protocols were performed...

tissue level myocardial perfusion is one of the most important prognostic factors after successful recanalisation of the occluded coronary artery in patients suffering acute st elevation myocardial infarction (stemi). the primary objective of the present study was to examine the relationship between videodensitometric myocardial perfusion parameters as assessed on coronary angiograms directly f...

In this paper we consider modelling of composite material with inclusions where the elastic material properties of both matrix and inclusions are uncertain and vary within prescribed bounds. Such mechanical systems, involving interval uncertainties and modelled by finite element method, can be described by parameter dependent systems of linear interval equations and process variables depending ...

Early repolarization pattern (ERP) may not be the entirely benign condition it was initially thought to be. In a recent metaanalysis, it was associated with increased risk and low to intermediate absolute incidence rate of arrhythmia death (1). However, the vast majority of subjects with ERP will never experience any malignant arrhythmia during their lifetime, and therefore, ability to identify...