نتایج جستجو برای: myocardial tissye engineering
تعداد نتایج: 419126 فیلتر نتایج به سال:
Bi-layered scaffolds with a 0°/90° lay-down pattern were prepared by melt-extrusion additive manufacturing (AM) using a poly(ester urethane) (PU) synthesized from poly(ε-caprolactone) diol, 1,4-butandiisocyanate and l-lysine ethyl ester dihydrochloride chain extender. Rheological analysis and differential scanning calorimetry of the starting material showed that compression moulded PU films wer...
BACKGROUND Regenerative therapies, including myocardial tissue engineering, have been pursued as a new possibility to repair the damaged myocardium, and previously the transplantation of layered cardiomyocyte sheets has been shown to be able to improve cardiac function after myocardial infarction. We examined the effects of promoting neovascularization by controlling the densities of cocultured...
Emerging trends for cardiac tissue engineering are focused on increasing the biocompatibility and tissue regeneration ability of artificial heart tissue by incorporating various cell sources and bioactive molecules. Although primary cardiomyocytes can be successfully implanted, clinical applications are restricted due to their low survival rates and poor proliferation. To develop successful car...
Introduction: Myocardial infarction followed by heart failure represents one of the major causes of morbidity and mortality, particularly in industrialized countries. Engineering and subsequent transplantation of contractile artificial myocardial tissue and, consequently, the replacement of ischemic and infarcted areas of the heart provides a potential therapeutic alternative to whole organ tra...
Cardiovascular disease is a major public health problem in the United States. In many survivors, extensive tissue damage from myocardial infarction leads to the development of congestive heart failure. Unfortunately, thus far, heart transplantation has remained the only viable treatment for end-stage congestive heart failure. Lack of available donor hearts has thus led to search for alternative...
Heart failure often develops as a consequence of the limited endogenous capacity for cardiac regeneration after acute myocardial infarction (MI). Cardiac progenitor cells (CPCs) that have been transplanted into hearts with MI can repair the damaged myocardium to some degree despite their low engraftment rates and limited evidence of transdifferentiation into myocardial cells. However, as progen...
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