The aggregation of the amyloidogenic polypeptide IAPP (Islet Amyloid Polypeptide, amylin) is believed to play a direct role in the death of pancreatic β-islet cells in type II diabetes. Preventing the initial aggregation event of IAPP is one strategy for slowing, and possibly preventing, the progression of this disease. Here, we investigate myricetin's potential as an inhibitor of IAPP aggregat...

Five structure-related myricetin galloylglycosides isolated from leaves of Acacia confusa were previously reported (Lee et al., 2000, J. Nat. Prod., 63, 710-712). However, the structure-activity relationships were not reported. In this research, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and inhibitory activities against semicarbazide-sensitive amine oxidase (SSAo) an...

Periodontitis that affects the underlying structures of the periodontium, including the alveolar bone, is a multifactorial disease, whose etiology involves interactions between specific bacterial species of the subgingival biofilm and the host immune components. In the present study, we investigated the effects of myricetin, a flavonol largely distributed in fruits and vegetables, on growth and...

There are multiple errors in the fifth sentence of the “Cell culture and treatments” subsection of the Materials and Methods. The correct sentence is: Differentiated L6 cells, given fresh media and reagents for 24 hours, were divided into five groups: a normoxia group (NORc) with vehicle, a control group (CONc) with vehicle, a myricetin group (10 μmol/L, this concentration was used based on pre...

BACKGROUND/OBJECTIVES Obesity-associated insulin resistance is a strong risk factor for type 2 diabetes mellitus. The aim of this study was to investigate the effect of myricetin on adiposity, insulin resistance, and inflammatory markers in mice with diet-induced insulin resistance. MATERIALS/METHODS Five-week-old male C57BL/6J mice were fed a basal diet, a high-fat, high-sucrose (HFHS) diet,...

The use of small molecules to arrest G-quadruplex structure has become a potential strategy for the development and design of a new class of anticancer therapeutics. We have studied the interaction of myricetin, a plant flavonoid and a putative anticancer agent, with human telomeric G-quadruplex TTAGGG(TTAGGG)3 DNA. Reverse transcription PCR data revealed significant repression in hTERT express...

As one of the natural herbal flavonoids, myricetin has attracted much research interest, mainly owing to its remarkable anticancer properties and negligible side effects. It holds great potential to be developed as an ideal anticancer drug through improving its bioavailability. This study was performed to investigate the effects of Pluronic-based micelle encapsulation on myricetin-induced cytot...

HIV infection by sexual transmission remains an enormous global health concern. More than 1 million new infections among women occur annually. Microbicides represent a promising prevention strategy that women can easily control. Among emerging therapies, natural small molecules such as flavonoids are an important source of new active substances. In this study we report the in vitro cytotoxicity...

Objective(s): Noise-induced hearing loss is one of the most common occupational diseases in industrialized countries and can be affected by various environmental and genetic factors. This study was designed to examine the effect of myricetin in preventing this disorder.Materials and Methods: Twenty-one Wistar rats were randomly divided i...

The antioxidant activity of myricetin, a natural flavonol found in fruits and vegetables, was determined in soybean oil methyl esters (SME) and compared with a-tocopherol and tert-butylhydroquinone (TBHQ) over a 90-day period employing EN 14112, acid value, and kinematic viscosity methods. Myricetin had greater antioxidant activity than a-tocopherol, but was inferior to TBHQ. Synergism was obse...