2-Methyl-8-quinolinol and sixteen 5-, 7-, and 5,7-substituted derivatives with fluoro, chloro, bromo, iodo, nitro, and amino substituents were tested for in vitro antifungal activity against five fungi, Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes. The 5,7-dichloro and 5,7-dibromo derivatives were the most fungitoxic of the compounds ...

CH2C12. The active fractions (CC14 and CH2C12, 300mg) were pooled and subjected to a flash silica column (CHCI3 : MeOHstep gradient). The active fraction (52 mg) eluted with 95:5 CHC13:MeOHand was subjected to a second flash silica column (hexanes : EtOAc step gradient). Final purification was obtained by normal phase HPLC (Sigma-Aldrich Nucleosil Silica 5 ,am, 25.0 cmX4.6 mm) with a solvent sy...