Two new antibiotics, A-218 and K-41, were isolated from strains identified as Streptomyces hygroscopicus. The antibiotics are characterized as polycyclic polyether compounds and are active against gram-positive bacteria.

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bond...

G. S. Collins and Y. Le Manach Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, and Departments of Anesthesia and Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Faculty of Health Sciences, Population Health Research Institute, McMaster University and the Perioperati...

Objective: To describe the design, validation, and implementation of the education material The world of malaria: let ́s learn to handle it in the community. Methods: The development of the educational material was carried out in the urban area of Buenaventura (main city in the Colombian Pacific coast) in 1995. The design was based on the results of a knowledge, beliefs, and practices study in t...