Compound 1 [(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin1-yl)methyl)-1-((1S,4S)-4-(isopropylcarbamoyl)cyclohexyl)-1Hbenzo[d]imidazol-2(3H)-ylidene)benzamide], a new, potent, selective anaplastic lymphoma kinase (ALK) inhibitor with potential application for the treatment of cancer, was selected as candidate to advance into efficacy studies in mice. However, the compound underwent mouse...

Metronidazole (MET) [systematic names: 1-(2-hy-droxy-eth-yl)-2-methyl-5-nitro-1H-imidazole and 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol] is a medication that is used to treat infections from a variety of anaerobic organisms. As with other imidazole derivatives, metronidazole is also susceptible to protonation. However, there are few reports of the structures of metronidazolium derivatives. ...

IN THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: 1-(2-hy-droxy-eth-yl)-2-methyl-5-nitro-1H-imidazol-3-ium perchlorate], C(6)H(10)N(3)O(3) (+)·ClO(4) (-), the cations are linked by inter-molecular N-H⋯O hydrogen bonds into zigzag chains along the c axis. The cations and anions are connected by O-H⋯O and C-H⋯O hydrogen bonds. A weak intra-molecular C-H⋯O hydrogen bond is also obse...

Sorption-desorption is one of the most important processes affecting the leaching of pesticides through soil because it controls the amount of pesticide available for transport. Subsurface soil properties can significantly affect pesticide transport and the potential for groundwater contamination. This research characterized the sorption-desorption of imidacloprid (1-[(6-chloro-3-pyridinyl)-met...

In this study, bis(salicylaldehyde)-4-methyl-1,2-phenylenediimine (BSMP) as a Schiff base ligand of N2O2-type and its Mn and Fe complex as M-BSMP catalyst were synthesized and characterized by UV-Vis, IR spectroscopy and elemental analysis. The efficiency of Fe- and Mn-BSMP catalysts was evaluated in the oxidative decarboxylation of arylacetic acids with tetra...

6-methyl-2-phenyl-7h-oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4h-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1h)-one (3).

The compound (μ-3,3',3'',3'''-{[2,5,8,15,18,21-hexa-oxatricyclo-[20.4.0.0(9,14)]hexa-cosa-1(22),9,11,13,23,25-hexa-ene-11,12,24,25-tetra-yl]tetra-kis-(methyl-ene)}tetra-kis-(1-methyl-1H-imidazol-2-yl))bis-[(η(4)-cyclo-octa-1,4-diene)rhodium(I)] bis-(hexa-fluoridophosphate) acetonitrile sesquisolvate dihydrate, [Rh2(C8H12)2(C40H42N8O6)](PF6)2·1.5CH3CN·2H2O, crystallized from acetonitrile under a...

The two achiral ligands tris(1-methyl-1H-imidazol-2-yl)methanol ((mim)3COH) and bis(1-methyl-1H-imidazol-2-yl)(3-methylpyridin-2-yl)methanol ((mim)2(mpy)COH) form on reaction with Fe(BF4)2∙6H2O, the octahedral low-spin complexes [Fe((mim)3COH)2](BF4)2∙MeCN (1) [Fe((mim)2(mpy)COH)2](BF4)2∙0.5MeCN (2). Both immediately rearrange to chiral [Fe4O4]-cubane clusters [Fe4(mim)3CO)4](BF4)4 (3) [Fe4(mim...

The structure of 1-methyl-2-(prop-2-en-1-ylsulfan-yl)-1H-imidazol-3-ium bromide, C7H11N2S(+)·Br(-), has monoclinic (P21/c) symmetry. In the crystal, the components are linked by N-H⋯Br and C-H⋯Br hydrogen bonds. The crystal structure of the title compound undeniably proves that methimazole reacts through the thione tautomer, rather than the thiol tautomer in this system.

In the title complex, [Cu(C(5)H(5)N(2)O(2))(C(14)H(18)N(3)O)(H(2)O)]·1.33H(2)O, the Cu(II) ion is coordinated in a slightly distorted square-pyramidal environment. The basal plane is formed by two N atoms from a 2-(5-ethyl-2-pyridyl-κN)-4-isopropyl-4-methyl-5-oxo-4,5-dihydroxy-imidazol-1-ide ligand and by one O atom and one N atom from a 5-methyl-1H-pyrazole-3-carboxyl-ate ligand. The apical po...