Nef proteins from human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have been found to associate with an active cellular serine/threonine kinase designated Nef-associated kinase (Nak). The exact identity of Nak remains controversial, with two recent studies indicating that Nak may be either Pak1 or Pak2. In this study, we investigated the hypothesis that such d...

JAMPQL, LEE M., AND FRANKLIN H. EPSTEIN. Sodiumpotassiumactivated adenosine triphosphatase and osmotic regulation by fishes. Am. J. Physiol. 218(2) : 607-611. 1970.-The specific activity of sodiumpotassium-activated adenosine triphosphatase is high in the gills of sa1twater teleosts, and low in the gills of elasmobranchs and freshwater teleosts. The activity of NaK-ATPase in gill filaments and ...

CD36 (also known as GPIV) deficiency is known to be responsible for the production of anti-Nak(a) antibodies in different clinical settings such as fetal/neonatal alloimmune thrombocytopenia (FNAIT), platelet transfusion refractoriness (PTR) and post-transfusion purpura (PTP). However, no data regarding the relevance of CD36 immunisation is currently available for China. In this study, healthy ...

Topical administration of 0.5% vanadate lowers intraocular pressure in monkey and rabbit eyes. This appears to be a consequence of a reduction in the rate of aqueous humor secretion, probably resulting from the inhibition of ciliary epithelium membrane. NaK ATPase. The ubiquitous vanadate and its interactions with catecholamines and ascorbate may play a role in regulating the sodium pump of the...

We study the performance of reliable and unreliable allnode broadcast over ad-hoc networks that use contentionbased channel access. To obtain analytical results while preserving hidden-terminal and node clustering characteristics of ah-hoc networks, we introduce a novel differentialequation fluid model for information flow through a network of cluster trees, where a spanning tree joins groups o...

Apparent blockage of monovalent cation currents by the permeating blocker Ca(2+) is a physiologically essential phenomenon relevant to cyclic nucleotide-gated (CNG) channels. The recently determined crystal structure of a bacterial homolog of CNG channel pores, the NaK channel, revealed a Ca(2+) binding site at the extracellular entrance to the selectivity filter. This site is not formed by the...

A growing number of network applications require the use of a reliable multicast protocol to disseminate data from a source to a potentially large number of receivers. This paper presents an analytic performance analysis of the packet delay incurred under three generic senderand receiver-initiated approaches towards reliable multicast. We focus on the host processing requirements of these proto...

shown in Fig. 3, which plot the maximum throughput achieved by each protocol when the number of receivers goes from 0 to 2000. The probability of a packet being lost is set to 0.02 and 0.1 in Fig. 3(a) and Fig. 3(b), respectively. We do not compare ELRP with the maximum throughout for tree-based protocols, because in a local group, a tree-based protocol is likely to have a single parent connect...

A numerical treatement of a model of semilinear parabolic equations on unbounded domain where the solutions blow up in finite time is presented. The numerical approximation requires selecting an appropriate bounded computational domain. The authors present suitable local absorbing boundary conditions (LABCs) in order to derive the bounded computational domain. A unified approach to derive such ...

Tumor necrosis factor alpha (TNFalpha) is a proinflammatory cytokine with pleiotropic immunological and biological activities. TNFalpha signaling is triggered by the engagement of soluble TNFalpha to two types of cell surface receptors, TNFR1 and TNFR2. This recruits cytosolic proteins to the intracellular domains of the receptors and initiates signaling to downstream effectors. In this study, ...