PURPOSE Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antiv...

IMPORTANCE The fellow eye of patients with unilateral neovascular age-related degeneration (nAMD) is at increased risk of developing late AMD. Several cohort studies have evaluated the prevalence of pseudodrusen and the association between pseudodrusen and late AMD in the fellow eye of patients with unilateral nAMD. However, these studies have limited sample sizes and their results are inconsis...

Disturbance in lipid metabolism has been suggested as a major pathogenic factor for age-related macular degeneration (AMD). Conventional lipid measures have been inconsistently associated with AMD. Other factors that can alter lipid metabolism include lipoprotein phenotype and genetic mutations. We performed a case-control study to examine the association between lipoprotein profile and neovasc...

Age-related macular degeneration (AMD) is one of the leading causes blindness in elderly, affecting macula retina and resulting vision loss. There are two types AMD, wet dry, both which cause visual impairment. Wet AMD called neovascular (nAMD) characterized by formation choroidal vessels (CNVs) macula. nAMD can be treated with intravitreal injections vascular endothelial growth factor (VEGF) i...

Purpose We determine the angiopoietin 2 (ANGPT2) gene as a new susceptibility gene for neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). Methods A total of 34 haplotype-tagging single-nucleotide polymorphisms (SNPs) were first genotyped in an exploratory Hong Kong Chinese cohort. Suggestive SNPs were replicated in a Shantou Chinese cohort and an ...

TOPIC To compare the accuracy of optical coherence tomography (OCT) with alternative tests for monitoring neovascular age-related macular degeneration (nAMD) and detecting disease activity among eyes previously treated for this condition. CLINICAL RELEVANCE Traditionally, fundus fluorescein angiography (FFA) has been considered the reference standard to detect nAMD activity, but FFA is costly...

NAMD is a portable parallel application for biomolecular simulations. NAMD pioneered the use of hybrid spatial and force decomposition, a technique used by most scalable programs for biomolecular simulations, including Blue Matter and Desmond which were described at Supercomputing 2006. This paper describes parallel techniques and optimizations developed to enhance NAMD’s scalability, to exploi...

Neovascular Age-related Macular Degeneration (nAMD) is one of the major factors for blindness and impaired visual acuity in elderly people. The aim this study was CFH gene screening Age-Related patients Indonesia. This performed 106 AMD 104 controls genomic markers Complement Factor H ( ). diagnosis carried out by retinal specialists based on color fundus photography optical coherence tomograph...

In this article, we review nonadiabatic molecular dynamics (NAMD) methods for modeling spin-crossover transitions. First, discuss different representations of electronic states employed in the grid-based and direct NAMD simulations. The nature interstate couplings is highlighted, with main focus on spin-orbit couplings. Second, describe three that have been used to simulate dynamics, including ...

Background Neovascular age-related macular degeneration (nAMD) is a common eye condition that can cause severe sight loss and blindness. Active disease is treated monthly until it becomes inactive, but regular monitoring by a hospital ophthalmologist is required as reactivation is common. The ECHoES trial was designed to assess whether, after appropriate training, community optometrists could m...