Nanotechnology is currently playing a significant role in the development of biosensors. The sensitivity and performance of biosensors improves drastically by incorporating nanomaterials and adopting new signal transduction technologies. With the rapid development of tools and fabrication processes , nanoscale sensors capable of interacting with extremely small molecules have been developed. Th...

An electrochemical DNA nanobiosensor was prepared by immobilization of a 20mer thiolated probe DNA on electro-deposited generation 4 (G4) poly(propyleneimine) dendrimer (PPI) doped with gold nanoparticles (AuNP) as platform, on a glassy carbon electrode (GCE). Field emission scanning electron microscopy results confirmed the codeposition of PPI (which was linked to the carbon electrode surface ...

The use of agrochemicals has increased considerably in recent years, and consequently, there has been increased exposure of ecosystems and human populations to these highly toxic compounds. The study and development of methodologies to detect these substances with greater sensitivity has become extremely relevant. This article describes, for the first time, the use of atomic force spectroscopy ...

Gastric cancer (GC) is the second leading cause of cancer-related deaths all over the world. miR-106a is a circulatory oncogenic microRNA (miRNA), which overexpresses in various malignancies, especially in GC. In this study, an ultrasensitive electrochemical nanobiosensor was developed for the detection of miR-106a using a double-specific probe methodology and a gold-magnetic nanocomposite as t...

The formation of microvascular networks plays essential roles in regenerative medicine and tissue engineering. Nevertheless, the self-organization mechanisms underlying the dynamic morphogenic process are poorly understood due to a paucity of effective tools for mapping the spatiotemporal dynamics of single cell behaviors. By establishing a single cell nanobiosensor along with live cell imaging...

Nanotechnology plays an important role in the development of biosensors. The sensitivity and performance of biosensors are improved by using nanomaterials through new signal transduction technologies. The development of tools and processes used to fabricate, measure and image nanoscale objects, has led to the development of sensors that interact with extremely small molecules that need to be an...

a sensitive monitoring of biological analytes, such as biomolecules (protein, lipid, dna and rna), and biological cells (blood cell, virus and bacteria), is essential to assess and avoid risks for human health. nanobiosensors, analytical devices that combine a biologically sensitive element with a nanostructured transducer, are being widely used for molecular detection of biomarkers associated ...

the importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. by taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. they have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. micrornas (mirnas) are o...