Hydroxyapatite is chemically related to the inorganic component of bone matrix as a complex structure with the formula of Ca10(OH)2(PO4)6. Previous studies have reported the application of microsized hydroxyapatite to bone regeneration, but the result is not satisfied. The limitation comes from the size of hydroxyapatite. In addition, the duration of treatment is very long. The advantages of hy...

The surfaces of hydoxyapatite ceramics were modified by the precipitation of octacalcium phosphate coating from aqueous solution and the biomimetic method synthesized nanohydroxyapatite coatings. Both coatings were deposited as continuous and uniform layers. It was demonstrated that the octacalcium phosphate coating was inappropriate for in-vitro osteoblast proliferation despite of good initial...

in this work we synthesized nano hydroxyapatite (hap)  by sol-gel method, then we functionalized hydroxyapatite nanoparticle by use of  3-aminopropyl trimethoxysilane (aptms) , to improve the loading and control release of sulfasalazine drug bonded to aptms. the drug release patterns from sulfasalazine loaded hap nanoparticles at ph value 8 for 6h, sulfasalazine loaded functionalized hap nanopa...

Calcium deficient nanohydroxyapatite (nanoHap) powders were synthesized by co-precipitation of calcium α-D-heptagluconate hydrate and diammonium hydrogen phosphate solutions. TEM and HRTEM images of powders after the drying of products showed that the reactant concentration affected the sizes and morphology of particles. Small changes were found in phase composition of nanoHap powders synthesiz...

the effects of chitosan/biopolymer (c/p) and nanohydroxyapatite/ biopolymer (nha/p) weight ratios on particle size and its uniformity, cross-linking density and nh2 content of nano-hydroxyapatite/chitosan/gelatin (nha/c/g) microspheres were investigated. microspheres were fabricated using water-in-oil emulsion. cross-linking of microspheres was performed using water soluble carbodiimide. partic...

The objective of this study was to synthetize europium-doped nanohydroxyapatite using a simple aqueous precipitation method and, thereafter, characterize and impregnate selected samples with 5-fluorouracil in order to explore the properties and the releasing capacity of this material. The nanohydroxyapatite was doped with 3, 5, 10, and 20 wt% of europium. The obtained samples were characterized...

Cages are used to regain stability of the anterior spinal column following vertebrectomy, which could prevent significant donor-site morbidity from the iliac autograft harvesting and the risk of disease transmission associated with the allograft. The hollow, porous, cylindrical nanohydroxyapatite/polyamide 66 (n-HA/PA66) cage is a new nonmetallic cage device made by combining nanohydroxyapatite...

BACKGROUND A nanohydroxyapatite-coated chitosan scaffold has been developed in recent years, but the effect of this composite scaffold on the viability and differentiation of periodontal ligament stem cells (PDLSCs) and bone repair is still unknown. This study explored the behavior of PDLSCs on a new nanohydroxyapatite-coated genipin-chitosan conjunction scaffold (HGCCS) in vitro as compared wi...

Objective: This randomized controlled trial aimed to compare nanohydroxyapatite with fluoride on managingpost ultrasonic scaling Dentine hypersensitivity (DH). Material and Methods: Thirty patients (aged 20-50years) post ultrasonic-scaling DH were included in this study. The sample was randomly divided into threeequal groups of 60 teeth each: the first group received material, second receivedfl...