نتایج جستجو برای: nanoliposomes
تعداد نتایج: 349 فیلتر نتایج به سال:
BACKGROUND The blood-brain barrier prevents many drug moieties from reaching the central nervous system. Therefore, glutathione-modulated nanoliposomes have been engineered to enhance the targeting of flucytosine to the brain. METHODS Glutathione-modulated nanoliposomes were prepared by thin-film hydration technique and evaluated in the primary brain cells of rats. Lecithin, cholesterol, and ...
liposomes have attracted great interest as efficient carriers for nutrients, drugs and other bioactive agents as well as ideal models for biological membranes. this article intends to provide an overview of liposomes and nanoliposomes definition as well as their properties and preparation methods. also it elaborates on various applications of nanoliposomes in nanotherapy including diagnostics, ...
dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. the aim of this study is to develop ocular dorzolamide hcl nanoliposomes (drz – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. nanoliposomes were prepared using reverse-phase evaporation vesicle (rev) and thin layer hydration (tlh...
Dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. The aim of this study is to develop ocular dorzolamide HCl nanoliposomes (DRZ – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. Nanoliposomes were prepared using Reverse-phase evaporation vesicle (REV) and thin layer hydration (TLH...
Survivin, an inhibitor of apoptosis protein is highly expressed in most cancers and considered as an attractive target for cancer antisense therapy. To vectorize antisense molecules, cationic nanoliposomes are generally used; however, their complexes are too instable, during shelf-life and upon exposure to blood components and extracellular matrix, to be used in-vivo. The present study a...
objective(s): the aim of this study was to determine cytotoxic effect of nanoliposomal form of lyophilized aqueous extract of ecballium elaterium fruit on gastric cell line (ags) using cell viability tests. methods: an aqueous extract of the fruits of ecballium elaterium was prepared. nanoliposomal form was also prepared by thin-film hydration method and stability size was determined by sem. th...
BACKGROUND It has been shown that topical nanoliposomal formulations improve burn healing process. On the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption; there is not such data available for burn eschar. Present investigation studies permeation of clindamycin phosphate (CP) through burn eschar from l...
Background and Objective: Methicillin-resistant Staphylococcus aureus is an important pathogen in medicine. Different studies have shown that some plant-derived materials loaded in a drug delivery system such as nanoliposomes could inhibit growth of resistant bacteria. Silymarin is an effective compound from medicinal plant Silybum mariunum L. The aim of this study was to prepare silymarin-load...
Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown. As most tumors exhibit a preferential switch to glycolysis, as described in the "Warburg effect", we hypothesize that ceramide nanoliposomes ...
Nanoliposomes are bilayer phospholipid vesicles used to encapsulate and deliver therapeutic agents. The study was aimed investigate the effects of critical variables on nanoliposomes characteristics. Imatinib mesylate-loaded were formulated by two-step emulsification process using a high-speed homogenizer system probe-type ultrasonicator. Box-Behnken design utilized optimize parameters. mean pa...
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