Polyoxometalate clusters (POMs) represent some of the largest non-biologically derived molecules so far synthesized as they occupy the 1–6 nm size range and exhibit a diverse variety of structures, assembled from a large “virtual combinatorial library” of building blocks. Whilst many tungsten POM clusters can be built in a controlled way, the designed assembly of giant molybdates is more diffic...

The mechanism that controls the self-assembly of complex polyoxometalate inorganic clusters in solution is a challenge because can contain anywhere from 6 to 368 metal ions single molecule and are commonly assembled under ʻone-potʼ reaction conditions. Furthermore, harnessing ʻself-assemblyʼ processes allows synthesis on length-scale with degree complexity which not easily accessed by more trad...

Superresolution light microscopy allows the imaging of labeled supramolecular assemblies at a resolution surpassing the classical diffraction limit. A serious limitation of the superresolution approach is sample heterogeneity and the stochastic character of the labeling procedure. To increase the reproducibility and the resolution of the superresolution results, we apply multivariate statistica...

An icosahedral closo-B₁₂²⁻ scaffold based nano-sized assembly capable of carrying a high payload of Gd³⁺-chelates in a sterically crowded configuration is developed by employing the azide-alkyne click reaction. The twelve copies of DO3A-t-Bu-ester ligands were covalently attached to an icosahedral closo-B₁₂²⁻ core via suitable linkers through click reaction. This nanomolecular structure support...

Potassium Channels allow potassium flux and are essential for the generation of electric current acrossexcitable membranes. Potassium Channels are also the targets of various intracellular controlmechanisms; such that the suboptimal regulation of channel function might be related to pathologicalconditions. Realistic studies of ion current in biologic channels present a major challenge for compu...