The present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. Fourier transform infrared spectroscopy (FTIR) and differential scannin...

The present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. Fourier transform infrared spectroscopy (FTIR) and differential scannin...

The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered liquid state into the nostril, and increase resistance against mucociliary clearance by sol-gel transition on nasal mucosa, as well improve drug absorption. Nanoparticle characterization showed that...

Calsequestrin (CASQ) is the major component of the sarcoplasmic reticulum (SR) lumen in skeletal and cardiac muscles. This calcium binding protein localizes to the junctional SR (jSR) cisternae where it is responsible for the storage of large amounts of Ca 2+ while it is usually absent, at least in its polymerized form, in the free SR. The retention of CASQ inside the jSR is partly due to its a...

Objective(s): The present study aimed to assess the in-vitro efficacy of nanoparticulate calcium sodium phosphosilicate mouthwash in the obstruction of dentinal tubules.Materials and Methods: This in-vitro, study was conducted on 120 sections obtained from extracted human premolars, which were etched with citric acid for two minutes and rinsed with distilled water. Afterwards, the section...