Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on developing new biosensing formats to push the limit of detection sensitivity. Nevertheless, QDs can be more than passive bio-probes or labels for biological imaging and cellul...

After a cardiac event, proper treatment and care of the damaged tissue is crucial in restoring optimal cardiac function and preventing future cardiac events. Recently, thymosin β4 has been found to play a vital role in cardiac cell health and development by regulating angiogenesis, inflammatory responses, and wound healing. We proposed that defined poly(ϵ-caprolactone) (PCL) nanoscaffolds coate...

BACKGROUND Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model. METHODS Graphene nanoscaffolds were p...

one of the main problems following road accidents is brain injury after which death and disability in the most active population occurs. considering the fact that there is no definite clinical treatment for repair of damaged brain tissue, the present study examined the effects of autologous adult neural stem/progenitor cells (ns/pcs) seeded in a nanoscaffold named puramatrix in acute brain inju...

BACKGROUND Development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. Gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. METHODS PLLA/PCL aligned fibrous scaffold was fabricated using electrospinning method. ADSCs...

A dual-functionalized nanoprobe was designed for highly sensitive and selective in situ evaluation of carbohydrates on living cells by integrating the specific carbohydrate recognition and enzymatic signal amplification of proteins on Au nanoparticles. A nanoscaffold of nanohorns functionalized with arginine-glycine-aspartic acid-serine tetrapeptide was also prepared on an electrode surface for...

Submit Manuscript | http://medcraveonline.com Abbreviations: CMGG: Carboxymethyl Guar Gum; BMMscs: Bone Marrow Derived Mesenchymal Stem Cells; DMEM: Dulbecco’s Modified Eagle Medium; FBS: Foetal Bovine Serum; Pen-Strep: Penicillin-Streptomycin; LPS: Lipopolysaccharide; Cocl2.6H2O: Cobalt Chloride Hexahydrate; PBS: Phosphate Buffered Saline; EDTA: Ethylene Diamine Tetra Acetic Acid; MTT: 3-(4, 5...

A novel device structure is developed, which uses easy-to-grow nano scaffold films to localize oxygen vacancies at vertical heterointerfaces. The strategy is to design vertical interfaces using two structurally incompatible oxides, which are likely to generate a high-concentration oxygen vacancy. Non-linear electroresistance at room temperature is demonstrated using these nano scaffold devices....