Tender and Swollen Joint Assessment, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Modified Nail Psoriasis Severity Index (mNAPSI), Mander/Newcastle Enthesitis Index (MEI), Leeds Enthesitis Index (LEI), Spondyloarthritis Research Consortium of Canada (SPARCC), Maastricht Ankylosing Spondylitis Enthesis Score (MASES), Leeds Dactylitis Index (LDI), Patient Globa...

Tofacitinib is an oral Janus kinase inhibitor. These post-hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52-week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b.i.d.); placebo-treated patients advanced to tofacitinib at week 16. Primary efficacy end-points were the proportions of patie...

OBJECTIVES To evaluate the effectiveness of adalimumab in patients with psoriatic arthritis (PsA) and identify predictors of good clinical response for joint and skin lesions. METHODS Patients received adalimumab 40 mg every other week in addition to standard therapy in this prospective, 12-week, open-label, uncontrolled study. Four definitions of good clinical response were used: > or =50% i...

Abstract Background/Aims Psoriatic nail disease is intimately linked to adjacent distal interphalangeal joint (DIP) disease, and it important ascertain whether DIP-nail complex behaves differently under different biological therapies. The aim of this analysis assess the effect ixekizumab (IXE) adalimumab (ADA) at individual digit level using Nail Psoriasis Severity Index (NAPSI) NAPSI resolutio...

ABSTRACT Introduction: Nail psoriasis treatment is challenging due to difficult drug delivery and systemic therapy toxicities. Self-dissolvable microneedle patches embedded with corticosteroids offers a potentially rapid, minimally invasive platform good efficacy minimal adverse side effects. Methods: We conducted 4-month prospective randomised controlled trial. Subjects psoriatic nails were re...

Nail psoriasis is considered a significant psychological and social problem causing functional impairment in affected patients. Nail changes hamper their daily and occupational activities and contribute to a worse quality of life. Almost 50% of patients with psoriasis vulgaris and up to 80% of patients with psoriatic arthritis are afflicted with nail lesions. The important correlation between p...

Involvement of sensitive or challenging body areas is an important treatment consideration since patients with psoriasis in these can have disproportionately greater burden disease. We assess comprehensive clearance by measuring the ability ixekizumab to achieve complete skin (PASI 100) up 5 years when multiple (scalp, nails, palmoplantar [pp] regions) are involved. Data were integrated from UN...

Introduction: Despite reports suggesting an association between COVID-19 mRNA vaccination and pericarditis myocarditis, detailed nationwide population-based data are sparsely available. We describe the incidence of myocarditis by age categories sex after from a mass programme in Singapore. Methods: The adjudicated cases following that were reported to vaccine safety committee January July 2021 ...

Introduction. The severity of the psoriatic process is associated with involvement scalp, genitals, fold zones and nails in process. selection effective therapy for psoriasis difficult localizations an urgent task modern dermatology. Aim. To evaluate effectiveness treatment moderate nail IL-17A inhibitor combination a combined betamethasone dipropionate + salicylic acid ointment. Material metho...