BACKGROUND Nasal allergen challenge (NAC) is useful to study the pathophysiology of rhinitis, and multiple challenges may more adequately approximate natural exposure. OBJECTIVE To determine the effect of 4 consecutive daily NAC, on clinical and inflammatory parameters in rhinitics with or without asthma. METHODS Rhinitic subjects were recruited: 19 with mild asthma and 13 without asthma. S...

Rhinovirus infections cause exacerbations of eosinophilic airway disease. The acute effects of allergen-challenge on nasal interleukin-8 (IL-8), eosinophil cationic protein (ECP), and alpha2-macroglobulin were examined in atopic subjects with common cold symptoms. Twenty-three patients with seasonal allergic rhinitis were inoculated with human rhinovirus 16 outside the pollen season. Diluent an...

BACKGROUND Nasya/Prevalin is a natural, drug-free nasal spray for treatment and prevention of allergic rhinitis. Because of its thixotropic property, it forms a barrier on the nasal mucosa, preventing allergen contact. This study assesses the clinical efficacy and safety of Nasya/Prevalin in a nasal provocation test with house dust mite allergens. METHODOLOGY/PRINCIPAL In this randomised, dou...

Elevated serum levels of antigen-specific immunoglobulin (Ig)E are often associated with allergic respiratory diseases. This parallel-group, randomised, double-blind, placebo-controlled trial was designed to study the influence of omalizumab on the early nasal response to allergen challenge reflected by symptom score and inflammatory marker levels in nasal lavage fluid (NAL). A total of 23 pati...

Eotaxin is an eosinophil-specific chemokine associated with the recruitment of eosinophils to the site of allergic inflammation. The aims of this study were to determine the expression of eotaxin in nasal biopsies from allergic and nonallergic individuals with chronic severe sinusitis, and to examine whether the expression of this chemokine is upregulated following allergen challenge in the nas...

INTRODUCTION The role of monokine induced by interferon-γ (IFN-γ, MIG/CXCL9), IFN-γ-inducible protein (IP-10/CXCL10), and IFN-inducible T cell α chemoattractant (I-TAC/CXCL11) in allergic inflammation has not been explored in detail in vivo. The aim of the study was to examine the changes in concentrations of MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11 in nasal lavages collected from healthy and a...

nasal obstruction) were recorded before challenge and every 15 minutes after challenge initiation. For the evaluation of nasal obstruction, we used visual analog scales (VASs); subjects marked a site on a 10-cm line corresponding to the symptom severity on which absence of symptoms was designated as 0 and worst imaginable symptom as 10. PIFR was measured using an In-check flow meter and nasal r...

nasal obstruction) were recorded before challenge and every 15 minutes after challenge initiation. For the evaluation of nasal obstruction, we used visual analog scales (VASs); subjects marked a site on a 10-cm line corresponding to the symptom severity on which absence of symptoms was designated as 0 and worst imaginable symptom as 10. PIFR was measured using an In-check flow meter and nasal r...

nasal obstruction) were recorded before challenge and every 15 minutes after challenge initiation. For the evaluation of nasal obstruction, we used visual analog scales (VASs); subjects marked a site on a 10-cm line corresponding to the symptom severity on which absence of symptoms was designated as 0 and worst imaginable symptom as 10. PIFR was measured using an In-check flow meter and nasal r...

Gender influences the incidence and/or the severity of several diseases and evidence suggests a higher rate of allergy and asthma among women. Most experimental models of allergy use mice sensitized via the parenteral route despite the fact that the mucosal tissues of the gastrointestinal and respiratory tracts are major sites of allergic sensitization and/or allergic responses. We analyzed all...