The objective of the present study was to formulate and evaluate nasal delivery system contains Ondansetron hydrochloride 4 mg/ml. Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like β-cyclodextrin, hydroxyl propyl βcyclodextrin at different concentrations. The optimized formulation contains 0.02% benzalkonium chloride as a pre...

Migraine is characterized by attacks of moderate to severe intensity headache, associated with some combination of severe disability, autonomic dysfunction such as gastric stasis, poor absorption from the small bowel, and associated symptoms such as nausea, vomiting, phonophobia, photophobia and worsening with exertion [1,2]. Oral medications may not be ideally suited for those migraineurs with...

BACKGROUND Different delivery modes may affect the susceptibility to allergic diseases. It is still unknown whether early intervention with probiotics would counteract this effect. OBJECTIVES The effect of different delivery modes on immune status and nasal symptoms was investigated on established allergic rhinitis (AR) mouse model. In addition, the immunoregulatory effects and mechanisms of ...

Nasal sprays and aerosols are becoming increasingly popular methods for drug delivery. The nasal route is a non-invasive way of administering drugs with rapid uptake into the bloodstream and is considered to be important for the systematic delivery of proteins and other macromolecules. A key parameter in defining the efficiency of nasal aerosol delivery systems is the particle size distribution...

Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...

Intranasal drug delivery – which has been practiced for thousands of years, has been given a new lease of life. It is a useful delivery method for drugs that are active in low doses and show no minimal oral bioavailability such as proteins and peptides. One of the reasons for the low degree of absorption of peptides and proteins via the nasal route is rapid movement away from the absorption sit...

Ayurveda is the ancient medical system in India that uses nasal therapy. During COVID -19 pandemic, ministry of AYUSH providedguidelines to boost immunity. The Nasya (nasal delivery) was one recommendations by immunity.Nasya has been still practice for various ailments like chronic rhinitis, headache, cervical spondylosis, Dyspnea, etc., but theknowledge about how works unclear.This review arti...

Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased.Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action. We have, herein, outlined the relevant aspects of nasal anatomy, physiology ...

The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...