Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was c...

conclusions our comprehensive literature review showed that our study was the first investigation in iran and the region, which determined the prevalence of nafld based on tissue diagnosis. we believe that the prevalence of nafld/nash in our donors can represent the overall prevalence in this age group in iran. results among 116 cases, two were diagnosed as probable nash. there was a significan...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...