In response to tissue injury acute inflammatory reactions occur that aim to restore homeostasis (Medzhitov, 2008). However, hampered resolution of inflammation can result in chronic inflammation and/or pathologic wound repair (Nathan and Ding, 2010). These conditions can result from excessive oxidative and inflammatory and/or overwhelmed adaptive response systems. They may also be triggered by ...

Diabetes mellitus (DM) is a major risk factor for micro and macrovascular complications (Kannel & McGee, 1979; King & Sheetz, 2002), and is associated with endothelial dysfunction, premature atherosclerosis (Johnstone et al., 1993; Nathan et al., 2003; Williams et al., 2005), and a reduced capability of neovascularization in ischemic conditions (Abaci et al., 1999). Hyperglycemia increases the ...

When using the K-nearest neighbours (KNN) method, one often ignores the uncertainty in the choice of K. To account for such uncertainty, Bayesian KNN (BKNN) has been proposed and studied (Holmes and Adams 2002 Cucala et al. 2009). We present some evidence to show that the pseudo-likelihood approach for BKNN, even after being corrected by Cucala et al. (2009), still significantly underest...

A seed shadow is the spatial distribution of all seeds dispersed from an individual plant (Janzen, 1970; Nathan and Muller-Landau, 2000; Schupp et al., 2002). The sum of seed shadows across all individuals in a population plus those seeds dispersed from other populations makes up seed rain. For vertebrate-dispersed species, seed shadows are the primary outcome of plant–frugivore interactions, y...

presented to The Society for Organ Sharing 2nd International Congress. Vancouver, BC, July 4–6, 1993.Nathan et al. 40American Journal of Transplantation 2003; 3 (Suppl. 4): 29–40