Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultan...

Medicinal plants play a vital role for the development of new drugs. the bioactive extract should be standardized on the basis of active compound. the bioactive extract should undergo safety studies. Almost, 70% modern medicines in India are derived from natural products. Medicinal plants play a central role not only as traditional medicines but also as trade commodities, meeting the demand of ...

The use of herbal medicines has been documented throughout recorded history including Assyrian clay tablets (2000 BC) and the Egyptian Ebers Papyrus (1550 BC) and in Ayurveda works from 900 BC. Arab scholars in Europe kept detailed notes regarding the use of medicinal plants. In the modern era, the research of natural bioactive molecules began with the isolation of morphine from opium latex in ...

The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the brain utilizing immunohistochemical method...

N-Butyl-phosphorotriamide (NBPT) is a fertilizer widely used for its urease inhibiting properties. Nevertheless, formulations currently commercialized are complex and do not avoid severe decrease of activity due to the low stability of the bioactive compound under acidic conditions. According to its structure, NPBT was thought to be able to interact with both polar additives, by its phosphorami...

Spearmint (Mentha spicata L.), oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) are used as traditional medicines, culinary herbs and food flavorings. All samples collected from Khuzestan province, Iran and plant extracts prepared using Clevenger apparatus. Antioxidant capacity and major parameters affecting antioxidant properties including total phenolics, flavonoids and vitamin C ...

Microbial secondary metabolites represent a rich, chemically-diverse source of bioactive compounds that have been exploited for applications in human medicine, agriculture, and industry [1-3]. Natural product fermentation bioprocesses have remained an important tool in efforts to acquire chemical diversity in bioactive compound libraries for lead generation [4]. In recent years, natural product...

Objective(s): To address the alarming problem of methicillin-resistant Staphylococcus aureus (MRSA), herein, a marine Streptomyces capable of producing an anti-MRSA compound has been studied.Materials and Methods: Strain MN41 was morphologically and physiologically characterized and then, molecularly identified using 16SrRNA analysis. To...